中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2009

自身免疫性肝炎患者血清中高迁移率族蛋白B1检测及临床意义

  • Published Date: 2009-02-20
  • Objective Adaption the method of ELISA, investigation the relationship between the human high mobility group box-1 protein (HMGB1) and autoimmune hepatitis (AIH) .Methods Coating the microwell plate using purified HMGB1 protein, detection the serum of the 165 AIH and 69 healthy respectively.Comparison the level of Anti-HMGB1 antibody in AIH and the healthy.Results The positive ratio of Anti-HMGB1 antibody in AIH more than that in healthy (78.7% VS 50.7%, P<0.05) , The linear regression analysis showed there were good correlation between the anti-HMGB1 antibody titer and the level of alanine transarninase (ALT) (correlation coefficient, r=0.968) .Conclusion HMGB1 is a crucial inflammatory protein in the progressing of AIH, there are good correlation between the anti-HMGB1 antibody titer and the stage of inflammation in AIH.

     

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