维生素D受体基因多态性与慢性乙型肝炎的相关性

Objective To investigate whether the vitamin D receptor gene polymorphisms are associated with the chronic hepatitis B.Methods 53 patients and 56 healthy peoples were studied.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphisms of FokI locus and BsmI locus of VDR gene.The comparision of frequence of genotype between the patients and controls were analyzed by Chi-square test.Results The BB genotype frequency in patients group was higher than that in normal control group (9.4% vs 0) , and there was a significant correlation (P<0.05) .The frequence of B allele in patients group was 19.8%, higher than that 8.9% in control group (P<0.05) .The frequence of genotype of FF、Ff and ff was 32.1%、52.8% and 15.1% in patients, and there was no significant correlation between patients and normal control group.At the sametime, the allele frequency of F in the chronic hepatitis B group was higher than that in normal control group (58.8% vs 50.9%) , but there was no significant correlation between them.Conclusion VDR gene polymorphisms may be related with chronic HBV infection, especially the allele B of BsmI locus may be an important factor related to the chronic HBV infection.