胆囊良恶性病变组织中IGFBP2和MMP9表达临床病理意义

Objective To study on the expressive levels of IGFBP-2 and MMP9 and detect their clinicopathological significances in benign and malignant lesions of gallbladder.Methods En VisionTM immunohistochemical method was used to detect the expressive levels of IGFBP2 and MMP9 in the routinely paraffin-embedded sections of the specimens from patients with gallbladder adenocarcinoma (n=108) and its pericancerous tissues (n=46) and chronic cholecystitis (n=35) .Results The positive rates and scores of IGFBP2 and MMP9 in gallbladder adenocarcinoma (54.6%, 2.26±1.67;59.3%, 2.88±1.15) were significantly higher than those in pericancerous tissues (28.3%, 1.05±1.21;32.6%, 1.16±1.10) and chronic cholecystitis (20.0%, 0.77±0.99;22.9%, 0.79±1.18) (P<0.01) .The positive rates and scores of IGFBP-2 and MMP9 were significantly lower in the cases of adenomataus canceraion, maximal diameter of mass<2cm, no-metastasis of lymphnode, no-invasion of regional tissues, and no-gallstone than those in the ones of moderately-or low-differentiated adenocarcinoma, maximal diameter of mass=2cm, metastasis of lymphnode, invasion of regional tissues and with-gallstone (P<0.05 or P<0.01) .The closely positive correlation was found between the expressive scores of IGFBP-2 and MMP9 in gallbladder adenocarcinoma.Conclusion The expressive levels of IGFBP-2 and MMP9 might be important biological markers for reflection the carcinogenesis, progression, biological behaviors and prognosis of gallbladder adenocarcinoma.IGFBP-2 might promote the biological synthesis of MMP9 in gallbladder adenocarcinoma tissues.