中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2008

世居藏族患者乙肝病毒基因型及其临床特点分析

  • Published Date: 2008-06-20
  • Objective Purpose right native Tibetan hepatitis B virus (HBV) genotype and clinical characteristics were analyzed.Methods Among 78 cases of patients with the native Tibetan HBV gene type, Quantitative analysis of hepatitis B virus DNA and liver function, two pairs of semi-HB, liver fibrosis, AFP, CEA, a B-ultrasonic testing of abdomen, and clinical characteristics were analyzed.Results Native Tibetan hepatitis B genotypes in patients with hepatitis B virus mainly B-and C-type, 78 cases of patients with B-41, C-37, B-and C-type pose no significant difference.C-type HBV DNA in patients with quantitative, the indicators of liver function, liver fibrosis, AFP, HBeAg positive rate, CEA-positive rate, the incidence of cirrhosis, liver cancer incidence, splenomegaly incidence was significantly higher than that in patients with type B (P<0.05) .Conclusion Native Tibetan HBV genotype mainly B, and C-type, C-type patients with cirrhosis, the incidence of liver cancer and liver fibrosis and liver dysfunction significantly higher than in patients with type B, the C in clinical right-native Tibetan hepatitis B patients should strengthen targeted prevention.

     

  • [1]Lee W M.Hepatitis B virus infection[J].NEngl J Med, 1997, 337 (24) :1733-1745.
    [2]李天一, 陈青锋, 吴国琳.乙肝病毒基因分型的临床意义[J].临床肝胆病杂志, 2007, 23 (2) :119-120.
    [3]崔超英.西藏地区的主要乙肝病毒基因型CD杂交型[J].西藏大学学报, 2002, 17 (3) :20-25.
    [4]王复元, 吴秀娟, 张大军, 等.克拉玛依地区HBV基因分型及进化分析[J].中国卫生检验杂志, 2007, 17 (3) :479-480.
    [5]张勇扬, 王爱平, 八桥弘, 等.南京地区99例乙肝病毒基因型及慢性感染临床表型[J].南京医科大学学报, 2007, 27 (2) :204-206.
    [6]谢碧霞, 江家骥.HBV基因型、亚型及其临床关系[J].中国人兽共患病学报, 2006, 22 (12) :1153-1155.
    [7]李春姬, 朱凤群, 狄鹏超.乙型肝炎病毒基因型检测与肝炎临床的相关性[J].西安交通大学学报:医学版, 2006, 27 (5) :452-454.
    [8]周莉, 于岩岩, 王勤环, 等.乙肝病毒基因型与患者临床预后关系的研究[J].临床肝胆病杂志, 2005, 21 (6) :324-326.
    [9]周光耀, 蒋道荣, 姚登福, 等.乙肝病毒基因分型及其临床意义[J].中国交通医学杂志, 2006, 20 (1) :49-50, 53.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2311) PDF downloads(909) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return