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Issue 5
May  2008
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Article Navigation >  Journal of Clinical Hepatology  > 2008  >  24(5): 367-368

转移抑制基因在肝癌中的实验研究

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  • Published Date: 2008-05-20
    Abstract
  • Objective To explore the expression of metastasis suppressor gene Kail in primary liver cancers and its relationship to clinicopathological feature.Methods The expression of Kail protein in fresh freezing tissures from 53 primary liver cancer patients, 17 normal were examined by immuno-histochemistry SP method.Results Kail expression was observed in 19 of 53 primary liver cancers (36%) and in 14 of 17 normal liver (82%) , the latter is higher (P<0.01) .It was significantly higher in early stage than that in late stage tumors (P<0.05) .Serous liver cancers showed significantly decreased staining of Kail when compared to macrosia cancers (P<0.01) .Furthermore, Kail expression in atypia (Ⅰ、Ⅱ) was higher than that in Ⅲ、Ⅳ (P<0.05) .Conclusion The downregulation of Kail may indicate metastasis, and relate with malignant degree of liver cancer.It can be used new prognostic marker of c primary liver ancer.

     

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    • References(6)
  • [1]Dong JT, Lamb PW, Rinker-Scdaeffer CW, et al.KAI1, a metas-tasis suppressor gene for prostate cancer on human chromosome11p11.2[J].Science, 1995, 268∶884~886.
    [2]Hashida H, Takabayashi A, Tokuhare T, et al.Integrin alpha3 ex-pression as a prognostic factor in colon cancer:association with MRP-1/CD9 and KAI1/CD82[J].Int J Cancer, 2002, 97 (4) ∶518~525.
    [3]Ow K, Delprado W, Fisher R, et al.Relationship between expres-sion of the KAI1 metastasis suppressor and other marker of advancedbladder cancer[J].J Pathol, 2000, 191 (1) ∶39~47.
    [4]Schindl M, Birner P, Bachtiary B, et al.KAI1 mestastasis suppres-sor protein in cervical cancer[J].Am J Pathol, 2002, 160 (4) ∶1542~1543.
    [5]Hemler ME, Mannion BA, Berditchevski F, et al.Association ofTM4SF protein with integrins:relevance to cancer[J].Biophys Acta, 1996, 1287∶67~71.
    [6]Monika S, Peter B, Gerhard B, et al.Downregulation of KAI1 me-tastasis suppressor protein is associated with a dismal prognosis in ep-ithelial ovarian cancer[J].Gynecol Oncol, 2001, 83 (1) ∶244~248.
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