应用ROC曲线评价酒精性肝病实验室诊断指标的价值

Objective To assess the value of carbohydrate-deficient transferrin (CDT) , γ-glutamyl transferase (GGT) , alanine amino transferase (ALT) and aspartate amino transferase (AST) in the diagnosis of alcoholic liver disease (ALD) .Methods Detect CDT of 38 patients with alcoholic liver disease (ALD) , 40 patients with NALD, 40 alcoholists and 40 healthy people by ion exchange color spectrum and immunoturbidimetry, Detect GGT, AST, ALT by the automatic biochemistry analyzer TBA-120FR.Analyze the data with receiver operating characteristic curve (ROC curve) .Results The area under curve (AUC) , the sensibility and specificity of CDT is respectively 0.894, 0.821 and 0.797;the three indexes of GGT is respectively 0.804, 0.800, 0.633;the three indexes of AST is respectively 0.525, 0.343, 0.574 in diagnosing ALD.Conclusion CDT and GGT are of certain value for the laboratory diagnosis of ALD and CDT is a better auxiliary diagnosis index than GGT.