C-fos、EGFR在肝癌、肝硬化中表达的研究

Objective To investigate the expression of transcriptioin factor C-fos in human hepatoma carcinoma and hepatic cirrhosis tissue, and the correlation between C-fos and EGFR in HCC tissue.Methods By using immuno-histochemistry, we studied the C-fos expression patterns in 51 cases of hepatocellular carcinoma tissues、51cases of para-carcinoma tissues、15 cases of hepatic cirrhosis tissues、10 cases of normal liver tissues and the expression of EGFR in 47 cases of HCC tissues.Results Normal liver tissue, hepatic cirrhosis tissue and hepatoma malignant tissues have different C-fos expression patterns and related to progression of hepatopathy (P<0.05) , in HCC tissue the expression of C-fos and EGFR have no apparent correlation (P>0.05) .Conclusion The overexpression of C-fos in hepatocellular carcinoma and hepatic cirrhosis tissue suggest it participate in the tumorigenesis and development of hepatocellular carcinoma and hepatic cirrhosis, but it maybe lead to HCC through other mechanism except EGFR signal pathway.