自身免疫性肝病的临床与病理学特点分析

Objective To analyze the clinical and histopathological characteristics of autoimmune liver disease (ALD) , and to explore the diagnostic criteria.Methods By using descriptive diagnosis standard and scoring system which was newly revised by the International Autoimmune Hepatitis Group Report, 25 cases of autoimmune liver disease were chosen to analyze the histopathological feature and to observe the number, ratio and distribution of CD138 positive cells by means of argyrophil reaction (by Grimeliu's) , Hematoxylin-Eosin (HE) staining and immunohistochemical staining.Results There were 9 cases (36%) of pure AIH patients and 13cases (52%) of pure PBC patients among the cases, the rest 3cases (12%) were over-lapped synthesis.The female patients with autoimmune hepatopathy was 19 cases, ALD mainly affects middle and old aged female patients;The levels of serum alkaline phosphatase (ALP) and serum gamma glutamy transpeptidase (r-GT) were very high;The main histopathological change was characterized of chronic hepatitis, the infiltration of lymphocytes, mononuclear cells and plasma cells in the portal tract or periportal area were found in the liver biopsie;The number of plasma cells in the ALD group were significantly higher than that in the CHB group [ (7.1±5.2) ]/HP and (3.3±2.0) /HP, P<0.05].Conclusion The increase of plasma cells in liver biopsy is possibly significant for diagnosis of ALD.