前S1抗原在诊断HBeAg阴性慢性乙型肝炎病毒复制中的作用

Objective To investigate the role of hepatitis B virus-preS1 (HBV-preS1) in detecting the replication of virus and predicting the prognosis of HBeAg-negative hepatitis B.Methods Using ELISA method.blood sample of 150 HBeAg-negative hepatitis B patients were analyzed about preS1 and HBVDNA comparatively.HBeAg、HBcAg and PreS1Ag in tissue by immunohistochem is try method.Results The coincidence rates of preS1 and HBVDNA were 62.7% and 66% respectively (P=0.398) .The results of preS1 and HBVDNA detection coincided greatly.Intracellular HBeAg、HBeAg and PreS1Ag account for 78%、58.7% and 61.3% respectively.Positive rate of expressing HBeAg, PreS1Ag are little less than HBeAg, but near between PreS1Ag and HBcAg.There are no significant difference by x2 test (P=0.476) .Contlusion PreS1 can reflect the relication of HBV sensitively for those who are HBeAg-negative.