Relationship of cytokines and osteoporosis in patients with hepatitis B cirrhosis

Wang YiGuo; Liu Qian; Wang WenQi; Chen ZiPing; Yan MingXian

Issue 3

Mar. 2006

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Article Navigation > Journal of Clinical Hepatology > 2006 > 22(3): 184-186

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细胞因子与乙肝肝硬化骨质疏松的关系

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Published Date: 2006-03-20

Abstract

Abstract

To study the relationship between cytokines and osteoporosis in patients with hepatitis B cirrhosis.Bone mineral desity (BMD) and serum levels of BGP、IL-1β、IL-6、TNF-α、urine crosslaps were detected in 61 cirrhosis patients and 30 agematched healthy controls.BMD and the serum levels of BGP in patients with hepatitis B cirrhosis were lower than those in control group.And the serum levels of BGP were much lower in OP group than those in NOP group.The leels of serum BGP had positive relation with the changes of BMD.A significant negative relation was found between urine crosslaps and BMD in OP group but there were no significant relation between them in NOP group.The serum levels of IL-1β、IL-6、TNF-α and urine crosslaps were higher in cirrhosis group than those in the controls, and were much higher in OP group than in NOP group.BMD had negative relations with serum levels of cytokines and urine crosslaps.Osteoporosis exists in cirrhosis patients.Elevation of serum IL-1β、IL-6、TNF-α can accelerate bone resorption and cause osteoporosis.Decrease of IL-1β、IL-6、TNF-α may be very important for prevention and treatment of osteoporosis.
- hepatitis B cirrhosis,
- serum cytokine,
- urine crosslaps,
- osteoporosis,

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[1] 中华医学会.病毒性肝炎防治方案[J].中华内科杂志, 2001, 40∶62-68.

[2] Solerio E, Isaia G, Innarella R, et al.Osteoporosis:still a typ icalcomplication of primary b iliary cirrhosis?[J].D ig L iver D is, 2003, 35∶39-46.

[3] Santolaria F, Gonzalez Reim ers E, Perez Manzano Jl, et al.Os-teopen ia assessed by body composition analysis is related to malnutri-tion in alcoholic patients[J].A lcohol, 2000, 22∶147-57.

[4] Bonde M, Qvist P, Fledelius C, et al.Immunoassay for quantifyingtypy 1 collagen degradation products in ru ine evaluated[J].C linChem, 1994, 40∶2022-2025.

[5] 郭世绂, 罗先正, 邱贵兴.骨质疏松基础与临床[M].天津:津科学技术出版社, 2001∶127-143.

[6] Mark C, Horow it Z.Cytok ines and estrogen in bone:anti-osteo-protic effects[J].S icience, 1993, 260∶626-627.

[7] Burgess T, Q ian Y, Kaufman S, et al.The ligand for osteoprotegerin (OPGL) d irectly activates mature osteoclasts[J].Cell B iol, 1999, 145∶527-38.

[8]孙永良, 张立煌, 方海林, 等.病毒性肝炎患者IL-1、IL-6、TNF-α活性的检测[J].中华微生物和免疫学杂志, 1994, 14∶187-189.

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沈阳化工大学材料科学与工程学院沈阳 110142

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细胞因子与乙肝肝硬化骨质疏松的关系

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细胞因子与乙肝肝硬化骨质疏松的关系

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