To study the cytology mechanism of emodin on anti-hepatic fibrosis.Hepatic stellate cells (HSC) were isolated, cultured and intervened with emodin (low-, medium-and high-dose groups:5, 10, 20 mg/L) .The proliferation and collagen synthesis of HSC were detected.The hyaluronic acid (HA) or laminin (LN) of HSC culture medium were analyzed.The results showed that emodin inhibited the proliferation and collagen, HA and LN synthesis of HSC in a dose-dependant manner.The results suggested that the direct inhibitory effect of emodin on the proliferation and extracellular matrix synthesis of HSC may be its main mechanism on anti-hepatic fibrosis.
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