病毒性肝炎患者血清胰岛素样生长因子结合蛋白3浓度的测定及对肝功能的评价

To investigate its level in patients with different kinds of viral hepatitis and its assessment on liver function, the serum level of insulin-like growth factor binding protein-3 (IGFBP-3) was measured by ELISA in 10 healthy controls, 10 cases with acute hepatitis, 10 cases with moderate degree chronic hepatitis, 11 cases with severe degree chronic hepatitis, 12 cases of severe ( ) hepatitis and 11 cases of cirrhosis, whose results were 4891.63±1482.91、4243.88±1086.02、3361.38±584.11、3021.63±946.48、1951.13±791.96 and 1146.93±443.15 ng/ml, respectively.Compared with healthy controls, serum IGFBP-3 levels in patients with viral hepatitis were much lower except acute hepatitis.The serum IGFBP-3 level decreases as the damage of liver function aggravates.There was significant positive correlation between serum IGFBP-3 and serum albumin, prealbumin, while negative with serum prothrombin time, total serum bilirubin and direct serum bilirubin.No significant correlation was found between serum IGFBP-3 and ALT, AST.Serum IGFBP-3 level is a good marker for the evaluation of liver function.