Hepatic chymase content in chronic hepatitis and hepatic fibrosis

Yin MingShi; Po HongXin; Zhou ZhenXia; Han XueJi; Tai YongRi

Issue 3

Mar. 2005

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2005 > 21(3): 161-162

PDF( 117 KB)

肝组织中糜酶浓度在慢性肝炎肝纤维化中的意义

Published Date: 2005-03-20

Abstract

Abstract

To investigate spatial relatioship betwwen human chymase and fibrosis in liver specimens affected by chronic hepatitis.The chymase levels were ditermined by using the method of enzyme-linked immunosorbant assay (ELISA) in 45 cases of chronic hepatitis.Mast cell distribution in the specimens was determined immunohistochemically by using anti-chymase antibody.Hepatic chymase concentrations in S3 and S4 cases were greater than in S1 and S2 , 〔S3+S4= (31.3±24.6) ng/mg vs.S1+S2= (5.7±4.8) ng/mg, P<0.01〕.Cells immunoreactive for chymase were seen throughout portal areas and intralobular sinusoidal walls, largely colocalizing with flbrosis.Chymase appears to be involved in hepatic fibrosis in chronic hepatitis.
- chymase,
- chronic hepatitis,
- mast cell,
- hepatic fibrosis,
- angiotensin

FullText(HTML)

References(8)

References

[1]YoshikawaH, TasakaK.Suppressionofmastcellactivationbyglucocorti coid[J].ArchImmunolTherExp (Wars2) , 2000, 48∶487-495.

[2]SatomuraK, ShimizuS, NagatoT, etal.Establishmentofanassaymethod forhumanmastcellchymase[J].ⅡepatolRes, 2002, 24∶361-367.

[3]YoshikawaH, TasakaK.Suppressionofmastcellactivationbyglucocorti coid[J].ArchImmunolTherExp (Wars2) , 2000, 48∶487-495.

[4]GinsburgH, Ben-DavidE.Mastcellgrowthonfibroblastmonolayers∶two-cellentities[J].Immunology, 1998, 45∶371-380.

[5]FarrellDJ, HinesJE, WallsAF, etal.Intrahepaticmastcellsinchronic liverdisease[J].Hepatology, 1995, 22∶1175-1181.

[6]TaniK, OgushiF, WawanoT, etal.Chymaseisapotentchemoattractant forhumanmonocytesanneutrophils[J].JleukocBiol, 2000, 67∶585-589.

[7]宋怀宇, 韩丽辉、朱菊人.慢性乙型肝炎、肝硬化患者肝组织中肾素-血管紧张素系统mRNA的表达及意义[J].中华肝脏病杂志, 2004, 12 (2) ∶109.

[8]YoshijiH, KuriyamaS, YoshiJ, etal.AngiotensinⅡtype1receptorinter actionisamajorforliverfibrosisdevelopmentinrats[J].Hepatology, 2001, 34∶745-747.

Relative Articles

[1]	Yuan HaiNing, Luo GuangHan, Deng YiMing. Effect of combination treatment of Adefovir and r-IFN to the hepatic fibrosis caused by hepatitis B[J]. Journal of Clinical Hepatology, 2008, 24(4): 254-255.
[2]	Ou XiaoJuan, Wang XiaoMing, Wang BaoEn, Wang TaiLing, Ma Hong, You Hong, Jia JiDong. Reevaluation of diagnostic value of serum fibrosis markers to liver fibrosis staging in patients with chronic hepatits B[J]. Journal of Clinical Hepatology, 2007, 23(6): 413-414.
[5]	Yin MingShi, Po HongXin, Han XueJi, Tai YongRi, Zhou ZhenXia. Increased chymase in livers with autoimmune disease:Co-localization with fibrosis[J]. Journal of Clinical Hepatology, 2005, 21(1): 9-12.
[6]	Lu ZhenYa, Wang QunYan, Rao WeiQiang, Cai WeiMin, Liu RongHua. The relationship between serum leptin levels and the levels of fibrosis marks in patients with hepatitis B.[J]. Journal of Clinical Hepatology, 2004, 20(2): 85-86.
[7]	Shen FengJun, Yin ChengHong, Ma Hong, Ma XueMei, Jia JiDong, Wang BaoEn, Zhu YueKe, Liu TianHui. Expression of angiotensin Ⅱ type 1 receptors mRNA in rat experimental biliary fibrosis[J]. Journal of Clinical Hepatology, 2002, 18(5): 279-281.
[8]	Liang ZhuShi, Chen ZhuYing, Xie ChongJia, Gan ChuLin, Mo MuLong, Wu GuiXiong. The relatinship between the level of serum TBA and the degree of inflammation on chronic hepatitis[J]. Journal of Clinical Hepatology, 2002, 18(4): 211-212.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (2244) PDF downloads(775)

肝组织中糜酶浓度在慢性肝炎肝纤维化中的意义

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

肝组织中糜酶浓度在慢性肝炎肝纤维化中的意义

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content