肝硬化伴自发性细菌性腹膜炎患者血浆及腹水降钙素原检测临床意义

To explore the clinical significance of plasma and ascitic procalcitonin (PCT) levels in cirrhotic patients with spontaneous bacterial peritonitis (SB) . Plasma and ascitic PCT levels in 62 ascitic patients (SBP 41 and non SBP 21) were detected by immunoluminometric assay, and compared with TNF-α、IL-6 levels. Plasma and ascitic PCT、TNF-α and IL-6 levels were significantly higher in SBP group than that in non SBP group (P<0.01) . In diagnosis of SBP, the positive predictive value (non SBP group x+2SD as the cutoff value) was the highest by plasma PCT than by the others, while the highest negative predictive value was ascitic IL-6. Plasma PCT、TNF-α and IL-6 levels in the death at admission were significantly higher than that in the survivals at the same time, but no in ascitic fluid. Plasma PCT level can be used as a useful indicator to the diagnosis and prognosis in cirrhotic patients with SBP.