To study Ginsenosides induced differentiation of human hepatocellular carcinoma (HCC) cells SMMC-7721, the morphologic changes and the expression of telomerase activity were observed with light, electronmicroscope and TRAP (telomeric repeat amplification protocol) .It showed that Ginsenosides could induce condensation of nuclear, vacuolar degeneration of mitochondria, reduction of microvillus, and so on.In this research, Ginsenosides can not inhibit telomerase activity, but it can suppress human hepatoma cells proliferation by the probale way of induing differentiation.
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