To determine the functional state of class Ⅰ presenting pathway for antigens in hepatocellular carcinoma (HCC) , the expression of TAP and HLA-Ⅰ antigens were detected in 30 cases of HCC and 28 cases of tissues-surrounding tumor by immunohistochemistry. The results showed most HCC and tissues-surrounding tumor tested had strong expression of TAP and HLA-Ⅰ antigens, there was no statistical difference between them (x 2<0.02, P>0.05) . It was suggested that there could be a functional class Ⅰ presenting pathway for antigens in HCC. These make it possible that cytotoxic T cells can kill the HCC cells, and provide experimental basis for design for HCC CTL eptope peptide vaccine.
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