饮酒与原发性肝癌关系的调查——附吉林省1057例原发性肝癌病因学分析

To definite the synergism between alcohol intake and hepatitis virus infection in causing with primary hepatocellular carcinoma (PHC) in Jilin province. A case-control study were performed to investigat alcohol intake and hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in 1057 newly diagnosed PHC cases and 3171 non-hepatic diseases admitted to the 3 main hospitals in Jilin province. The odds ratio (OR) for alcohol intake of (40-100) g/d and >100g/d was 1.41 and 3.04, respectively. The OR for alcohol intake of (40-100) g/d and >100g/d was 18.82 and 31.15 when patient infected HBV, 32.02 and 47.63 when patient infected HCV, respectively. The OR for alcohol intake of (40-100) g/d and >100g/d was 79.39 and 121.42 when patient coinfect HBV and HCV, respectively. In 452 patients who examined HBV-DNA, the positive rate of HBV-DNA with non-alcohol intake was 26.15% and increased to 49.07% and 70.56% with alcohol intake of (40-100) g/d and >100g/d, respectively. The positive rate of HBV-DNA was the highest (78.21%) in HBsAg and anti-HBc and anti-HBe positive with alcohol intake of >100g/d. Alcohol intake could increased the risk of causing PHC in patients who infected HBV or HCV or coinfect with HBV and HCV. Synergism was found between HBV infection and HCV infection and alcohol intake in causing PHC.