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Issue 6
Jun.  2002
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Article Navigation >  Journal of Clinical Hepatology  > 2002  >  18(6): 344-345

血清丙氨酸氨基肽酶(AAP)测定在诊断肝胆疾病中的应用

  • Published Date: 2002-06-20
    Abstract
  • To study the diagnostic value of serum alanine aminopeptidase (AAP) activity in both liver and biliary tract diseases. An automated assay was used to analyse serum AAP activities of 229 patients with hepatobiliary diseases and 70 normal individuals. The serum AAP levels of patients with liver cancer, chronic hapatitis and biliary obstruction were significantly higher than that of normal controls ( P<0 01) . There were positive correlation between serum AAP level and that of γ-GT?ALP and had no correlation with the T-Bil, ALT. The specifity of AAP for the diagnosis of hepatobiliary diseases was better than that of other indicator. Serum AAP is a sensitive and specific indicator for diagnosis of hepatobiliary diseases.

     

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    • References(8)
  • [1]Mueller PW, Phillips DL, Steinberg KK. Alanine aminopeptidase in Serum: automated optimized assay, and effects of age, sex, smoking, and alcohol consumption in a selected population[J]. Clin Chem, 1987, 33∶363-366.
    [2]Favaloro EJ, Browning T, Nandurkar H. The hepatobiliary disease marker serum alanine aminopeptidase predominantly comprises an isoform of the haematological myeloid differentiation antigen and leukaemia marker CD-13/gp150[J].Clin Chim Acta, 1993, 81-90.
    [3]Look AT, Ashmun RA, Shapiro LH, et al. Human myeloid plasma membrane glycoprotein CD-13 (gp150) is identical to aminopeptidase N[J]. J Clin Invest, 1989, 83∶1299-1307.
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