高胆固醇饮食对胆结石形成的研究

To form gallstones in dogs by feeding high cholesterol diet and to study the reason.Gallstone animal model was formed inducing by feeding 0.3% high cholesterol diet for 6 weeks and studied on the serum cholesterol, triglyceride (TG) level, bile cholesterol and cholesterol crystal.The gallstones were found in the all dogs by feeding high cholesterol diet for 4 weeks.Gallstones were 1mm-11mm in diameter.The serum cholesterol, triglyceride (TG) level increased significantly ( P<0 01 ) .Cholesterol and crystal cholesterol in bile increased greatly.Serum cholesterol, triglyceride level increased significantly and cholesterol and crystal cholesterol in bile increased greatly by feeding on high cholesterol diet.It is suggested that abnormal cholesterol metabolism plays an important role in gallstone formation.