In order to evaluate the response to interferon in chronic hepatitis B patients with HBV C promotor mutants, HBV core promotor genic fragments were amplified by using mismatched PCRcombined with direct sequencing.There were 47 (52.8%) cases with mutations in BCP region, in which 24 cases were treated with interferon, in 89 patients with CHB, and 12 cases (50%) have responses to interferon in observed group.21 cases were treated with interferon in 42 cases with wild type strain infection, of which 18 (85.7%) have responses to interferon.There was statistic difference between the two groups.The rate of ALT renormal and HBVDNA negative in the wild type group was significant higher than in the mutant group ( p <0.05) .The rate from mutant-type return to the wild type in treatment group (38.9%) was higher than in control group ( p <0.05) .The prevalent accumulaion of mutation in coinfectiontype might been eliminated after interferon treatment.These results suggest that the BCP mutation is not induced by interferon treatment, but it might reduce the effect of interferon.It may be sensitive actually that the mutant type have response to the interferon therapy, only might it need longer time with big dosage of interferon to clear the virus.
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