中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2000
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胸腺肽α1治疗重症肝炎的免疫调节研究

  • Published Date: 2000-02-20
  • WT5”BZ]To study immune regulation of Tymosion α 1 (Tα 1) Eighteen patients with severe hepatitis were treated by Tα 1 The levels of LSP, TNF, IL-2R, IL-4, IL-6, CD + 8CD + 4 in the serum were observed before and after Tα 1 therapy Before treatment, the levels of LSP, TNF, IL-2R, IL-6, and CD + 8 increased, and levels of IL-4, and CD + 4 decreased in the patients At the end of treatment, the levels of LSP, TNF, IL-2R, IL-6 and CD + 8 decreased, and levels of IL-4 and CD + 4 increased The studies showed Tα 1 is an immune regulation It can reduce immune damage of liver-cells in severe hepatitis [WT5”HZ]

     

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  • 〔1〕AndoKTakashiMoriyamaLucaGguidottietal MachanismsofClassⅠRestrictedImmunopathologyATransgenicMouseModelofFulminantHepati tisJExpMed , 1993 , 78∶15 41
    〔2〕黄自存 , 张国良 , 周大 , 等 胸腺肽α1 联合干扰素α1 b治疗慢性病毒性乙、丙型肝炎 中国新药杂志 , 1997, 2∶90
    〔3〕BaumannCABadamchianMGoldsteinAl ( 195 5 ) Tα1 antagonizesinducedapoplosisofdevelopingthymocytesinvitroMolCellBiol啨s 毢啨a (abstract2 0 72 )
    〔4〕SekiyamaKDyoshibaMThomsonAWetal Circulatingproinflammatorycytokines (IL -1pTNFαandIL -6) andIL -1receptorantagonist (IL -ΙRa) infulminantHepaticfailureClinExpImmunol 1994。 98∶71
    〔5〕FrancescoPDGaziano -RCombinedeffectoffluconasoleandthymosincα1 onsystemiccandidasisinmiceImmunopressedbymorphineTreatmentsClinExpImmunol 1994。paper 42 6
    〔6〕FukudaRIshimuraNNguyenTXetal TheexpressionofIL -2IL -4andInterferongam (IFNr) mRNAUsingliver, biopsisatdifferentphaseofa cutexacerbationofChronicHepatitisBClinExpImmunol1995。 10 0∶446
    []〔7〕裕石明 , 张立煌 , 方梅林。等 IL -4对重症肝炎患者外周血单核细胞IL -1α表达调节研究 , 中华传染病杂志 , 1998, 16 ( 3 ) ∶14 4
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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