Role and potential significance of peroxisome proliferator-activated receptors in liver diseases

Shuaixia FENG; Ying XU; Han HAN

doi:10.3969/j.issn.1001-5256.2023.07.034

Volume 39 Issue 7

Jul. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(7): 1747-1753

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Role and potential significance of peroxisome proliferator-activated receptors in liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.07.034

Shuaixia FENG,
Ying XU^{,
,},
Han HAN^{,
,}

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Research funding:

National Natural Science Foundation (82173946);

Shanghai Natural Science Foundation of China (21ZR1460500);

Youth Project of National Natural Science Foundation of China (82004162);

Shanghai Youth Science and Technology Talents Sail Program (20yf1449500)

More Information

Corresponding author: XU Ying, xuying.911@163.com (ORCID: 0000-0002-4645-3094); HAN Han, pashanhan@126.com (ORCID: 0000-0001-6454-876X)
Received Date: 2022-10-09
Accepted Date: 2022-11-11
Published Date: 2023-07-20

Abstract

Abstract

Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear estrogen receptor family, and they are involved in a variety of physiological and pathological processes in the human body and play important roles in cellular metabolism, inflammation, and cancer. At present, there are three known subtypes of PPAR, i.e., α, β/δ, and γ. Studies have shown that PPARs are highly expressed in the liver and are widely involved in various physiological and pathological activities such as liver energy metabolism, oxidative stress, and inflammation, and they are also closely associated with the progression of liver diseases. This article reviews the role of PPAR in common liver diseases such as viral hepatitis, metabolic associated fatty liver disease, cholestatic liver disease, liver fibrosis, and primary liver cancer, and the current status of their application in the treatment of liver diseases.
- Peroxisome Proliferator-Activated Receptors,
- Liver Diseases,
- Inflammation

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References

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Role and potential significance of peroxisome proliferator-activated receptors in liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.07.034

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