Clinical and pathological features of drug-induced liver injury with different types of bile duct injury: An analysis of four cases

Tianpeng ZHANG; Lihong YE; Hongxia GAO; Jinhong DONG; Chongkui WANG

doi:10.3969/j.issn.1001-5256.2023.07.021

Volume 39 Issue 7

Jul. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(7): 1665-1672

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Clinical and pathological features of drug-induced liver injury with different types of bile duct injury: An analysis of four cases

DOI: 10.3969/j.issn.1001-5256.2023.07.021

1.
Department of Coloproctology, Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China
2a.
Department of Pathology, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China
2b.
Endoscopy Room, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China
2c.
Department of Oncology, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China
3.
Experiment Center, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

Research funding:

Medical Science Research Project of Hebei Province (20221688)

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Corresponding author: WANG Chongkui, sjzwck@163.com (ORCID: 0000-0002-3040-8600)
Received Date: 2022-10-24
Accepted Date: 2022-11-30
Published Date: 2023-07-20

Abstract

Abstract

Objective To investigate the clinical, biochemical, pathological, disease course, and prognostic features of drug-induced liver injury (DILI) patients with different types of bile duct injury. Methods Four patients who were diagnosed with bile duct injury-type DILI by liver biopsy in Shijiazhuang Fifth Hospital, from March 2015 to October 2010 were selected, and related data were collected, including clinical data, laboratory examinations, radiological examination, and prognosis.The semi-quantitative score was determined for liver pathological morphology, and each indicator was compared between the four patients. Results Bile duct injury-type DILI was more common in female patients, and most patients tended to have a good prognosis.Clinical symptoms, liver biochemical parameters, and prognosis varied with the site, grade, scope, regeneration, and repair of bile duct injury. Conclusion Liver biopsy is still the gold standard for making a definite diagnosis of bile duct injury-type DILI, understanding the condition of lesions, and judging the prognosis of this disease.
- Chemical and Drug Induced Liver Injury,
- Cholestasis,
- Pathological Conditions, Signs and Symptoms

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References

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Clinical and pathological features of drug-induced liver injury with different types of bile duct injury: An analysis of four cases

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Clinical and pathological features of drug-induced liver injury with different types of bile duct injury: An analysis of four cases

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