Role of purine signaling in liver immune regulation

Faxiang MA; Zhengkun TU

doi:10.3969/j.issn.1001-5256.2023.06.036

Volume 39 Issue 6

Jun. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(6): 1488-1496

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Role of purine signaling in liver immune regulation

DOI: 10.3969/j.issn.1001-5256.2023.06.036

Faxiang MA,
Zhengkun TU^{,
,}

Laboratory of Tumor Immunology, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

Jilin Province Science and Technology Development Plan Project Natural Science Foundation Project (20190201245JC)

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Corresponding author: TU Zhengkun, tuzhengkun@hotmail.com (ORCID: 0000-0001-6803-2015)
Received Date: 2023-02-04
Accepted Date: 2023-03-05
Published Date: 2023-06-20

Abstract

Abstract

Purines are mainly composed of ATP, NAD⁺, and nucleic acid. In addition to their key intracellular functions, NAD⁺, ATP, and their hydrolyzed products (including ADP, AMP, and adenosine) are important extracellular signals involved in physiological processes and pathological conditions. Purine signaling plays an important role in immune regulation of liver microenvironment. This article mainly summarizes the regulatory effect of purine signaling on immune cells in the liver and the effect of purine signaling on the progression of liver diseases by regulating the inflammatory and anti-inflammatory responses of immune cells in the liver.
- Liver Diseases,
- Adenosine Triphosphate,
- Inflammation,
- Immunomodulation

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References(73)

References

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Role of purine signaling in liver immune regulation

DOI: 10.3969/j.issn.1001-5256.2023.06.036

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Role of purine signaling in liver immune regulation

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