Value of five scoring systems in predicting the severity of hyperlipidemic acute pancreatitis: A comparative analysis

Yuanzhen WANG; Yaling YUN; Juan XIE; Liya HUANG

doi:10.3969/j.issn.1001-5256.2023.06.020

Volume 39 Issue 6

Jun. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(6): 1391-1397

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Value of five scoring systems in predicting the severity of hyperlipidemic acute pancreatitis: A comparative analysis

DOI: 10.3969/j.issn.1001-5256.2023.06.020

1.
Department of Gastroenterology, General Hospital of Ningxia Medical University, Ningxia 750004, China
2.
Department of Gastroenterology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, Ningxia 750004, China

Research funding:

National Natural Science Foundation of China (82260572);

Natural Science Foundation of Ningxia (2023AAC03575)

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Corresponding author: HUANG Liya, txmbw@126.com (ORCID: 0000-0002-5464-2776)
Received Date: 2022-10-19
Accepted Date: 2022-12-08
Published Date: 2023-06-20

Abstract

Abstract

Objective To investigate the value of pancreatitis activity scoring system (PASS) score, Bedside Index for Severity in Acute Pancreatitis (BISAP) score, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE-Ⅱ) score, harmless acute pancreatitis score (HAPS), and Ranson score in evaluating the severity and prognosis of hypertriglyceridemia acute pancreatitis (HTGAP). Methods A retrospective analysis was performed for the clinical data of 300 patients with HTGAP who were admitted to General Hospital of Ningxia Medical University from January 2016 to January 2022, and according to the disease severity, these patients were divided into mild acute pancreatitis (MAP) group, moderate-severe acute pancreatitis (MSAP) group, and severe acute pancreatitis (SAP) group. Clinical data and the above scores were compared between the three groups. The chi-square test was used for comparison of categorical data between groups; an analysis of variance was used for continuous data with homogeneity of variance, and the Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data between groups. The receiver operating characteristic (ROC) curve was plotted according to disease severity, and related indicators were compared in terms of the area under the ROC curve (AUC). Results There were significant differences between the three groups in PASS score (F=219.351, P < 0.01), Ranson score (χ²=83.084, P < 0.01), APACHE-Ⅱ score (χ²=43.388, P < 0.01), and BISAP score (χ²= 50.785, P < 0.01). Compared with the other four scoring systems in evaluating and predicting disease severity, PASS score had the highest sensitivity of 0.945 and the largest AUC of 0.963, followed by Ranson score with a sensitivity of 0.655 and an AUC of 0.819. Conclusion For patients with HTGAP, PASS score can more accurately assess the severity and prognosis of HTGAP patients and thus holds promise for clinical application.
- Pancreatitis, Acute Necrotizing,
- Hypertriglyceridemia,
- Severity of Illness Index

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References

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Value of five scoring systems in predicting the severity of hyperlipidemic acute pancreatitis: A comparative analysis

DOI: 10.3969/j.issn.1001-5256.2023.06.020