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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 6
Jun.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(6): 1267-1273

Research advances in kidney-tonifying therapy for patients with HBeAg-positive chronic HBV infection

DOI: 10.3969/j.issn.1001-5256.2023.06.002

  • Department of Hepatology, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518033, China

Research funding:

National Science and Technology Major Project during the 13th Five-year Plan Period (2018ZX10725505-002);

Tong Guangdong Famous TCM Studio of Guangdong Province 

More Information
  • Corresponding author: TONG Guangdong, tgd755@163.com (ORCID: 0000-0002-8577-574X)
  • Received Date: 2023-03-31
  • Accepted Date: 2023-04-14
  • Published Date: 2023-06-20
    Abstract

  • Chronic HBV infection is an important phase in the natural history of HBV, but there are still controversies over the treatment of this stage. Traditional Chinese medicine has had unique advantages in the prevention and treatment of viral hepatitis since ancient times and plays an important role in prevention and treatment of viral hepatitis in China. Based on the pathological process of chronic HBV infection, the team of Department of Hepatology in Shenzhen Hospital of Traditional Chinese Medicine believes that the core pathogenesis of chronic HBV infection is "kidney deficiency and epidemic toxin lurking in liver blood" and established kidney-tonifying therapy for the treatment of chronic HBV infection. Under the support of the project of Prevention and Treatment of Major Infectious Diseases such as AIDS and Viral Hepatitis in The Eleventh Five Year Plan, The Twelfth Five Year Plan, and The Thirteenth Five Year Plan, the team has conducted studies on the regularity of syndromes and a series of clinical studies and investigated the clinical efficacy of kidney-tonifying therapy through multicenter, randomized, double-blind, placebo-controlled studies, thereby exploring the application and mechanism of traditional Chinese medicine treatment in patients with chronic HBV infection. However, there are still difficulties in the pathogenesis and treatment of chronic HBV infection, and with the inheritance, innovation, and modernization of traditional Chinese medicine, it is believed that traditional Chinese medicine can provide reliable regimens for the treatment of chronic HBV infection.

     

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