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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 3
Mar.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(3): 677-683

Application of near-infrared fluorescence imaging in hepatectomy of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.03.031

  • Department of Hepatobiliary Surgery, The First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Research funding:

National Natural Science Foundation of China (General Program) (81773177)

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  • Corresponding author: AN Jiaze, anjiaze68@163.com (ORCID: 0000-0002-5839-4992)
  • Received Date: 2022-06-09
  • Accepted Date: 2022-07-27
  • Published Date: 2023-03-20
    Abstract
  • Multimodality therapy based on surgery is the main treatment method for hepatocellular carcinoma (HCC), and hepatectomy requires the removal of primary tumor and the preservation of normal liver tissue to the maximum extent. However in clinical surgery, it is difficult to accurately identify tumor tissue and its boundary with visual inspection and palpation, which often results in under-resection or over-resection. Near-infrared fluorescence (NIRF) imaging is a real-time noninvasive imaging technique with low costs and high sensitivity, and extensive studies have been conducted to investigate its application in guiding surgical resection of tumors. With the development of fluorescence imaging system and fluorescence probe, intraoperative tumor localization and boundary determination can be realized to make the surgery more accurate. This article reviews the development of various NIRF probes for intraoperative navigation in HCC and discusses current challenges and potential opportunities of these imaging probes.

     

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    • References(42)
  • [1]
    General Office of National Health Commission. Standard for diagnosis and treatment of primary liver cancer (2022 edition)[J]. J Clin Hepatol, 2022, 38(2): 288-303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.

    国家卫生健康委办公厅. 原发性肝癌诊疗指南(2022年版)[J]. 临床肝胆病杂志, 2022, 38(2): 288-303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.
    [2]
    AUFHAUSER DD Jr, SADOT E, MURKEN DR, et al. Incidence of occult intrahepatic metastasis in hepatocellular carcinoma treated with transplantation corresponds to early recurrence rates after partial hepatectomy[J]. Ann Surg, 2018, 267(5): 922-928. DOI: 10.1097/SLA.0000000000002135.
    [3]
    SHINN J, LEE S, LEE HK, et al. Recent progress in development and applications of second near-infrared (NIR-Ⅱ) nanoprobes[J]. Arch Pharm Res, 2021, 44(2): 165-181. DOI: 10.1007/s12272-021-01313-x.
    [4]
    KENRY, DUAN Y, LIU B. Recent advances of optical imaging in the second near-infrared window[J]. Adv Mater, 2018, 30(47): e1802394. DOI: 10.1002/adma.201802394.
    [5]
    ZHENG F, HUANG X, DING J, et al. NIR-Ⅰ dye-based probe: a new window for bimodal tumor theranostics[J]. Front Chem, 2022, 10: 859948. DOI: 10.3389/fchem.2022.859948.
    [6]
    REINHART MB, HUNTINGTON CR, BLAIR LJ, et al. Indocyanine green: historical context, current applications, and future considerations[J]. Surg Innov, 2016, 23(2): 166-175. DOI: 10.1177/1553350615604053.
    [7]
    ISHIZAWA T, MASUDA K, URANO Y, et al. Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma[J]. Ann Surg Oncol, 2014, 21(2): 440-448. DOI: 10.1245/s10434-013-3360-4.
    [8]
    ISHIZAWA T, FUKUSHIMA N, SHIBAHARA J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging[J]. Cancer, 2009, 115(11): 2491-2504. DOI: 10.1002/cncr.24291.
    [9]
    SATOU S, ISHIZAWA T, MASUDA K, et al. Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma[J]. J Gastroenterol, 2013, 48(10): 1136-1143. DOI: 10.1007/s00535-012-0709-6.
    [10]
    MORITA Y, SAKAGUCHI T, UNNO N, et al. Detection of hepatocellular carcinomas with near-infrared fluorescence imaging using indocyanine green: its usefulness and limitation[J]. Int J Clin Oncol, 2013, 18(2): 232-241. DOI: 10.1007/s10147-011-0367-3.
    [11]
    PI ZH, LIU H, GONG SC. Application of indocyanine green fluorescence imaging in hepatobiliary surgery[J/OL]. Chin J Hepat Surg(Electronic Edition), 2021, 10(06): 555-558. DOI: 10.3877/cma.j.issn.2095-3232.2021.06.005.

    皮志恢, 刘辉, 龚帅昌, 等. 吲哚氰绿荧光成像技术在肝胆外科中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2021, 10(06): 555-558. DOI: 10.3877/cma.j.issn.2095-3232.2021.06.005.
    [12]
    ZHANG YM, SHI R, HOU JC, et al. Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging[J]. J Cancer Res Clin Oncol, 2017, 143(1): 51-58. DOI: 10.1007/s00432-016-2267-4.
    [13]
    XU Q, KOBAYASHI S, YE X, et al. Comparison of hepatic resection and radiofrequency ablation for small hepatocellular carcinoma: a meta-analysis of 16, 103 patients[J]. Sci Rep, 2014, 4: 7252. DOI: 10.1038/srep07252.
    [14]
    WANG JW, ZHANG YM. Research advances in methods for determination of tumor boundary in hepatectomy[J]. J Clin Hepatol, 2016, 32(2): 374-377. DOI: 10.3969/j.issn.1001-5256.2016.02.039.

    王金伟, 张雅敏. 肝切除术中确定肿瘤边界方法的研究进展[J]. 临床肝胆病杂志, 2016, 32(2): 374-377. DOI: 10.3969/j.issn.1001-5256.2016.02.039.
    [15]
    MIYATA A, ISHIZAWA T, TANI K, et al. Reappraisal of a dye-staining technique for anatomic hepatectomy by the concomitant use of indocyanine green fluorescence imaging[J]. J Am Coll Surg, 2015, 221(2): e27-e36. DOI: 10.1016/j.jamcollsurg.2015.05.005.
    [16]
    WANG TY, ZHU YF, SUN M, et al. Application of three-dimensional reconstruction combined with indocyanine green intraoperative navigation in diagnosis and treatment of liver cancer[J]. J Jilin Univ(Med Edit), 2021, 47(4): 1014-1021. DOI: 10.13481/j.1671-587X.20210427.

    王天一, 朱玉峰, 孙淼, 等. 三维重建联合吲哚菁绿术中导航在肝癌诊断和治疗中的应用[J]. 吉林大学学报(医学版), 2021, 47(4): 1014-1021. DOI: 10.13481/j.1671-587X.20210427.
    [17]
    ZHENG JH, ZHAI ST, LIANG X. Laparoscopic portal territory hepatectomy (extended segment 5) by an indocyanine green fluorescent dual staining technique (video)[J]. J Gastrointest Surg, 2021, 25(1): 329-330. DOI: 10.1007/s11605-020-04764-7.
    [18]
    ITO D, ISHIZAWA T, HASEGAWA K. Laparoscopic positive staining of hepatic segments using indocyanine green-fluorescence imaging[J]. J Hepatobiliary Pancreat Sci, 2020, 27(7): 441-443. DOI: 10.1002/jhbp.726.
    [19]
    HE JM, ZHEN ZP, YE Q, et al. Laparoscopic anatomical segment Ⅶ resection for hepatocellular carcinoma using the Glissonian approach with indocyanine green dye fluorescence[J]. J Gastrointest Surg, 2020, 24(5): 1228-1229. DOI: 10.1007/s11605-019-04468-7.
    [20]
    KIM YS, CHOI SH. Pure laparoscopic living donor right hepatectomy using real-time indocyanine green fluorescence imaging[J]. J Gastrointest Surg, 2019, 23(8): 1711-1712. DOI: 10.1007/s11605-019-04217-w.
    [21]
    CHEN ZS, LIN KC, LIU JF. Application of three-dimensional visualization in surgical operation for primary liver cancer[J]. J Clin Hepatol, 2022, 38(3): 505-509. DOI: 10.3969/j.issn.1001-5256.2022.03.003.

    陈昭硕, 林科灿, 刘景丰. 三维可视化技术在原发性肝癌外科手术中的应用[J]. 临床肝胆病杂志, 2022, 38(3): 505-509. DOI: 10.3969/j.issn.1001-5256.2022.03.003.
    [22]
    GOTOH K, YAMADA T, ISHIKAWA O, et al. A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation[J]. J Surg Oncol, 2009, 100(1): 75-79. DOI: 10.1002/jso.21272.
    [23]
    INOUE Y, TANAKA R, KOMEDA K, et al. Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience[J]. World J Surg, 2014, 38(7): 1786-1794. DOI: 10.1007/s00268-014-2463-9.
    [24]
    SCHNEIDER AR, ZÖPF T, ARNOLD JC, et al. Feasibility and diagnostic impact of fluorescence-based diagnostic laparoscopy in hepatocellular carcinoma: a case report[J]. Endoscopy, 2002, 34(10): 831-834. DOI: 10.1055/s-2002-34299.
    [25]
    KAIBORI M, MATSUI K, ISHIZAKI M, et al. Intraoperative detection of superficial liver tumors by fluorescence imaging using indocyanine green and 5-aminolevulinic acid[J]. Anticancer Res, 2016, 36(4): 1841-1849.
    [26]
    CHUNG IW, ELJAMEL S. Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection[J]. Photodiagnosis Photodyn Ther, 2013, 10(4): 362-367. DOI: 10.1016/j.pdpdt.2013.03.007.
    [27]
    SHI C, WU JB, PAN D. Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy[J]. J Biomed Opt, 2016, 21(5): 50901. DOI: 10.1117/1.JBO.21.5.050901.
    [28]
    ZHAO NN, ZHANG CQ, ZHAO Y, et al. Application of targeting near-infrared fluorescence dye in the study of liver cancer models[J]. Chin J Comp Med, 2017, 27(3): 8-13. DOI: 10.3969/j.issn.1671-7856.2017.03.002.

    赵宁宁, 张彩琴, 赵勇, 等. 靶向性近红外荧光染料在肝癌模型研究中的应用[J]. 中国比较医学杂志, 2017, 27(3): 8-13. DOI: 10.3969/j.issn.1671-7856.2017.03.002.
    [29]
    WANG QZ, ZHANG C, LI L, et al. The application of heptamethine cyanine dye in optical imaging of hepatocellular carcinoma transplantation model[J]. Lab Anim Comp Med, 2018, 38(4): 250-254. DOI: 10.3969/j.issn.1674-5817.2018.04.002.

    王勤周, 张成, 李丽, 等. 七甲川菁荧光染料在肝细胞癌移植模型活体成像中的应用[J]. 实验动物与比较医学, 2018, 38(4): 250-254. DOI: 10.3969/j.issn.1674-5817.2018.04.002.
    [30]
    LI FQ, ZHANG SX, AN LX, et al. In vivo molecular targeting effects of anti-Sp17- ICG-Der-02 on hepatocellular carcinoma evaluated by an optical imaging system[J]. J Exp Clin Cancer Res, 2011, 30(1): 25. DOI: 10.1186/1756-9966-30-25.
    [31]
    HE H, TU X, ZHANG J, et al. A novel antibody targeting CD24 and hepatocellular carcinoma in vivo by near-infrared fluorescence imaging[J]. Immunobiology, 2015, 220(12): 1328-1336. DOI: 10.1016/j.imbio.2015.07.010.
    [32]
    ZHU D, QIN Y, WANG J, et al. Novel glypican-3-binding peptide for in vivo hepatocellular carcinoma fluorescent imaging[J]. Bioconjug Chem, 2016, 27(3): 831-839. DOI: 10.1021/acs.bioconjchem.6b00030.
    [33]
    QIN ZN, WANG JJ, WANG Y, et al. Identification of a glypican-3-binding peptide for in vivo non-invasive human hepatocellular carcinoma detection[J]. Macromol Biosci, 2017, 17(4): 1600335. DOI: 10.1002/mabi.201600335.
    [34]
    LU JX, WANG J, LING DS. Surface engineering of nanoparticles for targeted delivery to hepatocellular carcinoma[J]. Small, 2018, 14(5): 1702037. DOI: 10.1002/smll.201702037.
    [35]
    ZENG CT, SHANG WT, WANG K, et al. Intraoperative identification of liver cancer microfoci using a targeted near-infrared fluorescent probe for imaging-guided surgery[J]. Sci Rep, 2016, 6: 21959. DOI: 10.1038/srep21959.
    [36]
    ZHANG X, LI S, MA H, et al. Activatable NIR-Ⅱ organic fluorescent probes for bioimaging[J]. Theranostics, 2022, 12(7): 3345-3371. DOI: 10.7150/thno.71359.
    [37]
    CARR JA, FRANKE D, CARAM JR, et al. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green[J]. Proc Natl Acad Sci U S A, 2018, 115(17): 4465-4470. DOI: 10.1073/pnas.1718917115.
    [38]
    HU Z, FANG C, LI B, et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-Ⅰ/Ⅱ windows[J]. Nat Biomed Eng, 2020, 4(3): 259-271. DOI: 10.1038/s41551-019-0494-0.
    [39]
    DING F, LI C, XU Y, et al. PEGylation regulates self-assembled small-molecule dye-based probes from single molecule to nanoparticle size for multifunctional NIR-Ⅱ bioimaging[J]. Adv Healthc Mater, 2018, 7(23): e1800973. DOI: 10.1002/adhm.201800973.
    [40]
    REN Y, HE S, HUTTAD L, et al. An NIR-Ⅱ/MR dual modal nanoprobe for liver cancer imaging[J]. Nanoscale, 2020, 12(21): 11510-11517. DOI: 10.1039/d0nr00075b.
    [41]
    ZHAO M, LI B, WU Y, et al. A Tumor-microenvironment-responsive lanthanide-cyanine fret sensor for NIR-Ⅱ luminescence-lifetime in situ imaging of hepatocellular carcinoma[J]. Adv Mater, 2020, 32(28): e2001172. DOI: 10.1002/adma.202001172.
    [42]
    HERNOT S, van MANEN L, DEBIE P, et al. Latest developments in molecular tracers for fluorescence image-guided cancer surgery[J]. Lancet Oncol, 2019, 20(7): e354-e367. DOI: 10.1016/S1470-2045(19)30317-1.
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