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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 10
Oct.  2019
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Article Contents

Research advances in the mechanism of action of intestinal microecology in intrahepatic cholestasis

DOI: 10.3969/j.issn.1001-5256.2019.10.050
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  • Received Date: 2019-05-15
  • Published Date: 2019-10-20
  • Intrahepatic cholestasis(IHC) is a dysfunction of bile production,secretion,and excretion caused by various factors including genetics,immunity,inflammation,stones,and tumors,and therefore,the bile is not normally discharged into the duodenum and reversely flows into blood,which causes a series of clinical diseases with organic damage,metabolic disorders,and dysfunction. In recent years,with the deepening of clinical and basic research,intestinal microecology is found to play an important role in the development and progression of liver diseases. This article reviews the mechanism of action of intestinal microecology and inflammatory factors in intrahepatic cholestasis and explores the research advances in the role of probiotics in regulating intestinal flora stability and improving intestinal microenvironment,so as to provide a basis for clinical treatment,scientific research,and drug research and development.

     

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