|
[1] ISHIBASHI H,NAKAMURA M,KOMORI A,et al. Liver architecture,cell function,and disease[J]. Semin Immunopathol,2009,31(3):399-409.
|
|
[2] ISHIBASHI H,NAKAMURA M,KOMORI A,et al. Liver architecture,cell function,and disease[J]. Semin Immunopathol,2009,31(3):399-409.
|
|
[3] HORTON R. GBD 2010:Understanding disease,injury,and risk[J]. Lancet,2012,380(9859):2053-2054.
|
|
[4] CAMP JG,SEKINE K,GERBER T,et al. Multilineage communication regulates human liver bud development from pluripotency[J]. Nature,2017,546(7659):533-538.
|
|
[5] MARIOTTI V,STRAZZABOSCO M,FABRIS L,et al. Animal models of biliary injury and altered bile acid metabolism[J].Biochim Biophys Acta Mol Basis Dis,2018,1864(4 Pt B):1254-1261.
|
|
[6] HUCH M,DORRELL C,BOJ SF,et al. In vitro expansion of single Lgr5+liver stem cells induced by Wnt-driven regeneration[J]. Nature,2013,494(7436):247-250.
|
|
[7] TAKEBE T,SEKINE K,ENOMURA M,et al. Vascularized and functional human liver from an i PSC-derived organ bud transplant[J]. Nature,2013,499(7459):481-484.
|
|
[8] DIANAT N,DUBOIS-POT-SCHNEIDER H,STEICHEN C,et al. Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells[J]. Hepatology,2014,60(2):700-714.
|
|
[9] BROUTIER L,MASTROGIOVANNI G,VERSTEGEN MM,et al.Human primary liver cancer-derived organoid cultures for disease modeling and drug screening[J]. Nat Med,2017,23(12):1424-1435.
|
|
[10] OGAWA M,OGAWA S,BEAR CE,et al. Directed differentiation of cholangiocytes from human pluripotent stem cells[J].Nat Biotechnol,2015,33(8):853-861.
|
|
[11] SAMPAZIOTIS F,de BRITO MC,MADRIGAL P,et al. Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation[J]. Nat Biotechnol,2015,33(8):845-852.
|
|
[12] WU F,WU D,REN Y,et al. Generation of hepato-biliary organoids from human induced pluripotent stem cells[J]. J Hepatol,2019,70(6):1145-1158.
|
|
[13] HU H,GEHART H,ARTEGIANI B,et al. Long-term expansion of functional mouse and human hepatocytes as 3D organoids[J]. Cell,2018,175(6):1591-1606.
|
|
[14] NANTASANTI S,SPEE B,KRUITWAGEN HS,et al. Disease modeling and gene therapy of copper storage disease in canine hepatic organoids[J]. Stem Cell Reports,2015,5(5):895-907.
|
|
[15] KRUITWAGEN HS,OOSTERHOFF LA,VERNOOIJ I,et al.Long-term adult feline liver organoid cultures for disease modeling of hepatic steatosis[J]. Stem Cell Reports,2017,8(4):822-830.
|
|
[16] HUCH M,GEHART H,van BOXTEL R,et al. Long-term culture of genome-stable bipotent stem cells from adult human liver[J]. Cell,2015,160(1-2):299-312.
|
|
[17] SI-TAYEB K,NOTO FK,NAGAOKA M,et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells[J]. Hepatology,2010,51(1):297-305.
|
|
[18] TOUBOUL T,HANNAN NR,CORBINEAU S,et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development[J]. Hepatology,2010,51(5):1754-1765.
|
|
[19] SAMPAZIOTIS F,JUSTIN AW,TYSOE OC,et al. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids[J]. Nat Med,2017,23(8):954-963.
|
|
[20] GUAN Y,XU D,GARFIN PM,et al. Human hepatic organoids for the analysis of human genetic diseases[J]. JCI Insight,2017,2(17):e94954.
|
|
[21] OUCHI R,TOGO S,KIMURA M,et al. Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids[J]. Cell Metab,2019,30(2):374-384,e6.
|
|
[22] LIANG G,ZHANG Y. Genetic and epigenetic variations in i PSCs:Potential causes and implications for application[J].Cell Stem Cell,2013,13(2):149-159.
|
|
[23] LORENT K,GONG W,KOO KA,et al. Identification of a plant isoflavonoid that causes biliary atresia[J]. Sci Transl Med,2015,7(286):267r-286r.
|
|
[24] BAKTASH Y,MADHAV A,COLLER KE,et al. Single particle imaging of polarized hepatoma organoids upon hepatitis C virus infection reveals an ordered and sequential entry process[J]. Cell Host Microbe,2018,23(3):382-394.
|
|
[25] NIE YZ,ZHENG YW,MIYAKAWA K,et al. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells[J]. EBio Medicine,2018,35:114-123.
|
|
[26] CUGOLA FR,FERNANDES IR,RUSSO FB,et al. The Brazilian Zika virus strain causes birth defects in experimental models[J]. Nature,2016,534(7606):267-271.
|
|
[27] GARCEZ PP,LOIOLA EC,MADEIRO DCR,et al. Zika virus impairs growth in human neurospheres and brain organoids[J]. Science,2016,352(6287):816-818.
|
|
[28] TUVESON D,CLEVERS H. Cancer modeling meets human organoid technology[J]. Science,2019,364(6444):952-955.
|
|
[29] CAYO MA,MALLANNA SK,di FURIO F,et al. A drug screen using human i PSC-derived hepatocyte-like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia[J]. Cell Stem Cell,2017,20(4):478-489.
|
|
[30] VLACHOGIANNIS G,HEDAYAT S,VATSIOU A,et al. Patientderived organoids model treatment response of metastatic gastrointestinal cancers[J]. Science,2018,359(6378):920-926.
|
|
[31] LI M,IZPISUA BJ. Organoids-preclinical models of human disease[J]. N Engl J Med,2019,380(6):569-579.
|
|
[32] PENG WC,LOGAN CY,FISH M,et al. Inflammatory cytokine tnfalpha promotes the long-term expansion of primary hepatocytes in 3D culture[J]. Cell,2018,175(6):1607-1619.
|
|
[33] PARK SE,GEORGESCU A,HUH D. Organoids-on-achip[J]. Science,2019,364(6444):960-965.
|
|
[34] GJOREVSKI N,SACHS N,MANFRIN A,et al. Designer matrices for intestinal stem cell and organoid culture[J]. Nature,2016,539(7630):560-564.
|
|
[35] XIANG C,DU Y,MENG G,et al. Long-term functional maintenance of primary human hepatocytes in vitro[J]. Science,2019,364(6438):399-402.
|
DownLoad: