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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 5
May  2019
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Article Contents

Potential value of aquaporin-8 in treatment of liver diseases

DOI: 10.3969/j.issn.1001-5256.2019.05.047
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  • Received Date: 2018-11-08
  • Published Date: 2019-05-20
  • Aquaporins are involved in bile metabolism and cell signal transduction. This article briefly describes the role and mechanism of action of aquaporins in cholestatic liver disease, alcoholic liver disease, hepatic encephalopathy, and liver cancer and points out that aquaporin agonists may be a future direction of treatment of these liver diseases, which provides new ideas for the treatment of liver diseases.

     

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  • [1] BENGA G, POPESCU O, BORZA V, et al. Water permeability in human erythrocytes:Identification of membrane proteins involved in water transport[J]. Eur J Cell Biol, 1986, 41 (2) :252.
    [2] DENKER BM, SMITH BL, KUHAJDA FP, et al. Identification, purification, and partial characterization of a novel Mr 28, 000integral membrane protein from erythrocytes and renal tubules[J]. J Biol Chem, 1988, 263 (30) :15634-15642.
    [3] ZHOU YY, LI WG. The discovery of aquaporins and their relationship with human diseases[J]. Biol Teach, 2017, 42 (12) :2-3. (in Chinese) 周园园, 李卫国.水通道蛋白的发现历程及与人类疾病的关系概述[J].生物学教学, 2017, 42 (12) :2-3.
    [4] de GROOT BL, FRIGATO T, HELMS V, et al. The mechanism of proton exclusion in the aquaporin-1 water channel[J]. J Mol Biol, 2003, 333 (2) :279-293.
    [5] DENG P, YANG XS. Talk about aquaporin[J]. Biol Teach, 2015, 40 (6) :60-62. (in Chinese) 邓鹏, 杨晓霜.说说“水通道蛋白”[J].生物学教学, 2015, 40 (6) :60-62.
    [6] AGEMARK M, KOWAL J, KUKULSKI W, et al. Reconstitution of water channel function and 2D-crystallization of human aquaporin 8[J]. Biochim Biophys Acta, 2012, 1818 (3) :839-850.
    [7] PORTINCASA P, PALASCIANO G, SVELTO M, et al. Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease[J]. Eur J Clin Invest, 2010, 38 (1) :1-10.
    [8] BENGA G. Water channel proteins (later called aquaporins) and relatives:Past, present, and future[J]. Lubmb Life, 2010, 61 (2) :112-133.
    [9] ZHANG Q, ZHAO XX, SUN W. Research advances in the role of aquaporins in liver fibrosis and liver cirrhosis[J]. J Clin Hepatol, 2016, 32 (6) :1192-1195. (in Chinese) 张强, 赵相轩, 孙巍, 等.水通道蛋白在肝纤维化及肝硬化进程中的作用[J].临床肝胆病杂志, 2016, 32 (6) :1192-1195.
    [10] LEHMANN GL, LAROCCA MC, SORIA LR, et al. Aquaporins:Their role in cholestatic liver disease[J]. World J Gastroenterol, 2008, 14 (46) :7059-7067.
    [11] GRADILONE SA, GARCIA F, HUEBERT RC, et al. Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes[J]. Hepatology, 2003, 37 (6) :1435-1441.
    [12] HUEBERT RC, SPLINTER PL, GARCIA F, et al. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion[J]. J Biol Chem, 2002, 277 (25) :22710-22717.
    [13] CARRERAS FI, LEHMANN GL, FERRI D, et al. Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 292 (3) :g905-g912.
    [14] MARRONE J, LEHMANN GL, SORIA LR, et al. Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen-induced cholestasis[J]. Gene Ther, 2014, 21 (12) :1058.
    [15] YU FS, FAN YG, WU MJ, et al. New hypothesis for intrahepatic cholestasis[J]. J Jinzhou Med Univ, 2015, 36 (1) :90-91. (in Chinese) 于凤爽, 范永刚, 武民君, 等.肝内胆汁淤积机制的新假说[J].锦州医科大学学报, 2015, 36 (1) :90-91.
    [16] SORIA LR, MARRONE J, CALAMITA G, et al. Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels[J]. Hepatology, 2013, 57 (5) :2061-2071.
    [17] MEDRAA O-FERNANDEZ I, BESTETTI S, BERTOLOTTI M, et al. Stress regulates aquaporin-8 permeability to impact cell growth and survival[J]. Antioxid Redox Signal, 2016, 24 (18) :1031-1044.
    [18] ALMASALMEH A, KRENC D, WU B, et al. Structural determinants of the hydrogen peroxide permeability of aquaporins[J]. Febs J, 2014, 281 (3) :647-656.
    [19] LI J, ZHAO GX, SUN JY. Disrupted subcellular distribution of aquaporin-3, 8 and 9 promoted rat alcoholic liver disease[J]. Fudan Univ J Med Sci, 2018, 45 (2) :177-184. (in Chinese) 李静, 赵广西, 孙剑勇.水通道蛋白3、8和9的异常亚细胞分布参与大鼠酒精性肝病的发病[J].复旦大学医学版, 2018, 45 (2) :177-184.
    [20] XU YN, QING DX. Advances in molecular mechanisms of mitochondrial damage in alcoholic liver disease[J]. Int J Dig Dis, 2013, 33 (1) :17-20. (in Chinese) 许亚男, 卿笃信.酒精性肝病线粒体损伤分子机制的研究进展[J].国际消化病杂志, 2013, 33 (1) :17-20.
    [21] HOLMDAHL R, SAREILA O, PIZZOLLA A, et al. Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells[J]. Antioxid Redox Signal, 2013, 18 (12) :1463-1474.
    [22] JIN BY, MICHEL T. MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability.[J]. Proc Natl Acad Sci U S A, 2012, 109 (37) :14864-14869.
    [23] Al GHOULEH I, FRAZZIANO G, RODRIGUEZ AI, et al. Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy[J]. Cardiovasc Res, 2013, 97 (1) :134-142.
    [24] BIENERT GP, CHAUMONT F. Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide[J]. Biochim Biophys Acta, 2014, 1840 (5) :1596-1604.
    [25] MARCHISSIO MJ, FRANCS DE, CARNOVALE CE, et al. Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability[J]. Toxicol Appl Pharmacol, 2012, 264 (2) :246-254.
    [26] MARCHISSIO MJ, FRANCS DE, CARNOVALE CE, et al. Evidence for necrosis, but not apoptosis, in human hepatoma cells with knockdown of mitochondrial aquaporin-8[J]. Apoptosis, 2014, 19 (5) :851-859.
    [27] MOLINAS SM, SORIA LR, MARRONE J, et al. Acidosis-induced downregulation of hepatocyte mitochondrial aquaporin-8 and ureagenesis from ammonia[J]. Biochem Cell Biol, 2015, 93 (4) :417-420.
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