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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
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Article Contents

Direction and progress in research and development of anti-HBV drugs

DOI: 10.3969/j.issn.1001-5256.2016.06.043
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  • Published Date: 2016-06-20
  • Chronic hepatitis B(CHB) is considered as the most important risk factor for public health around the world,as well as the main reason for potential diseases to develop into liver cirrhosis and hepatocellular carcinoma.However up to now,there are few methods for the treatment of this lethal viral infection with poor therapeutic effects.At present,we have realized the necessity to develop new drugs.This article reviews the drugs currently available in market or under clinical trials,introduces several drugs with a promising future in each category of anti- HBV drugs,and points out the developmental direction of multi- effect combination of anti- HBV drugs in future,in order to provide the latest advances in HBV treatment for researchers working on HBV and experts engaged in healthcare.

     

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  • [1] Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment for chronic hepatits B:a 2015 update[J].J Clin Hapetol,2015,31(12):1941-1960.(in Chinese)中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版)[J].临床肝胆病杂志,2015,31(12):1941-1960.
    [2]MANZOOR S,SAALIM M,IMRAN M,et al.Hepatitis B virus therapy:what’s the future holding for us:the future[J].World JGastroenterol,2015,21(44):12558-12575.
    [3] Hepatits B foundation drug watch.Compounds in development for chronic hepatitis B[EB/OL].(2016-03-25)http://www.hepb.org/professionals/hbf_drug_watch.htm.
    [4]PREZ-CAMEO C,PONS M,ESTEBAN R.New therapeutic perspectives in HBV:when to stop NAs[J].Liver Int,2014,34(1):146-153.
    [5]YANG FQ,RAO GR.Research progress of therapeutic vaccines against hepatitis B[J].Infect Dis Info,2015,28(2):65-69.(in Chinese)杨富强,饶桂荣.乙型肝炎治疗性疫苗研究进展[J].传染病信息,2015,28(2):65-69.
    [6] XUE M,FAN F,DING L,et al.An autophagosome-based therapeutic vaccine for HBV infection:a preclinical evaluation[J].JTransl Med,2014,12:361.
    [7]WANG JZ,YANG DL.Immune modulation treatment of chronic hepatits B virus infection[J].Chin J Hepatol,2015,23(3):227-230.(in Chinese)王俊忠,杨东亮.免疫调节治疗慢性乙型肝炎病毒感染的研究进展[J].中华肝脏病杂志,2015,23(3):227-230.
    [8]MARTIN P,DUBOIS C,JACQUIER E,et al.TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBV-persistent mice[J].Gut,2015,64(12):1961-1971.
    [9]GANE EJ,LIM YS,GORDON SC,et al.The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection[J].J Hepatol,2015,63(2):320-328.
    [10]LANFORD RE,GUERRA B,CHAVEZ D,et al.GS-9620,an oral agonist of Toll-like receptor-7,induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees[J].Gastroenterology,2013,144(7):1508-1517.
    [11]BILLIOUD G,PICHOUD C,PUERSTINGER G,et al.The main hepatitis B virus(HBV)mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication[J].Antiviral Res,2011,92(2):271-276.
    [12]WU G,LIU B,ZHANG Y,et al.Preclinical characterization of GLS4,an inhibitor of hepatitis B virus core particle assembly.[J].Antimicrob Agents Chemother,2013,57(11):5344-5354.
    [13]WU Y,HAN L,YUAN YF.Meta-analysis of telbivudine and lamivudine in the treatment of chronic hepatitis B[J].China Med Herald,2014,11(28):11-13,18.(in Chinese)吴岩,韩璐,原永芳.替比夫定和拉米夫定治疗慢性乙型肝炎的Meta分析[J].中国医药导报,2014,11(28):11-13,18.
    [14]WANG J.Efficacy of lamivudine combined with adefovir dipivoxil in treatment of chronic hepatitis B cirrhosis[J].J Clin Exp Med,2014,13(6):498-500.(in Chinese)王婧.拉米夫定联合阿德福韦酯治疗慢性乙型肝炎肝硬化的疗效观察[J].临床和实验医学杂志,2014,13(6):498-500.
    [15] YANG HC,KAO JH.HBV cure-can we pin our hopes on immunotherapy?[J].Nat Rev Gastroenterol Hepatol,2015,12(3):129-131.
    [16]LIN CL,YANG HC,KAO JH.Hepatitis B virus:new therapeutic perspectives[J].Liver Int,2016,36(1):85-92.
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