中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
Turn off MathJax
Article Contents

Research advances in the role of aquaporins in liver fibrosis and liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2016.06.041
Research funding:

 

  • Received Date: 2016-01-05
  • Published Date: 2016-06-20
  • Liver fibrosis is the final outcome of various chronic liver diseases,and various cells,cytokines,and miRNAs are involved in the development and progression of liver fibrosis and liver cirrhosis.Hepatic fibrosis and pathologic angiogenesis are interdependent processes and promote each other,but the physiopathological mechanism of arterial capillary proliferation in liver fibrosis remains unknown.Aquaporins not only transport water molecules,but also promote angiogenesis.This article briefly introduces the expression of aquaporins in the hepatobiliary system and their physiological and biochemical characteristics and summarizes the role of aquaporins in the progression of liver fibrosis and liver cirrhosis,in order to provide new thoughts and guidance for aquaporins as the target in the treatment of liver fibrosis and liver cirrhosis.

     

  • loading
  • [1]DANCYGIER H,SCHIRMACHER P.Fibrogenic reaction[J].Clin Hepatology,2010,21(7):251-268.
    [2]LIM YM,KIM WR.The global impact of hepatic fibrosis and end-stage liver disease[J].Clin Liver Dis,2008,12(4):733-746.
    [3]ELPEK G.Angiogenesis and liver fibrosis[J].World J Hepatol,2015,7(3):377-391.
    [4]AGRE P,SASAKI S,CHRISPEELS MJ.Aquaporins:a family of water channel proteins[J].Am J Physiol,1993,265(2):f461.
    [5]IGUCHI H,ODA M,YAMAZAKI H,et al.Participation of aquaporin-1 in vascular changes and remodeling in cirrhotic liver[J].Med Mol Morphol,2013,46(3):123-132.
    [6]YOKOMORI H,ODA M,YOSHIMURA K,et al.Aquaporin-1associated with hepatic arterial capillary proliferation on hepatic sinusoid in human cirrhotic liver[J].Liver Int,2011,31(10):1554-1564.
    [7]YOKOMORI H,ODA M,YOSHIMURA K,et al.Aberrant expressions of aquaporin-1 in association with capillarized sinusoidal endothelial cells in cirrhotic rat liver[J].Med Mol Morphol,2010,43(1):6-12.
    [8]BENGA G.Birth of water channel proteins-the aquaporins[J].Cell Biol Int,2003,27(9):701-709.
    [9]XIN J,SUN TJ,ZHANG X,et al.Advances in aquaporin molecular targeted therapy and molecular targeted imaging[J].J Chin Clin Med Imaging,2014,25(11):807-810.(in Chinese)辛军,孙天娇,张新,等.水通道蛋白分子靶向治疗和分子靶向成像研究进展[J].中国临床医学影像杂志,2014,25(11):807-810.
    [10]VERKMAN AS,HARA-CHIKUMA M,PAPADOPOULOS MC.Aquaporins---new players in cancer biology[J].J Mol Med(Berl),2008,86(5):523-529.
    [11]PORTINCASA P,PALASCIANO G,SVELTO M,et al.Aquaporins in the hepatobiliary tract.which,where and what they do in health and disease[J].Eur J Clin Invest,2008,38(1):1-10.
    [12]BENGA G.Water channel proteins(later called aquaporins)and relatives:past,present,and future[J].IUBMB Life,2009,61(2):112-133.
    [13]LIU K,WANG GF,WU XJ,et al.The research progress in the physiology of aquaporins in the hepatobiliary system[J].Parenter Enteral Nutr,2012,5(19):316-318.(in Chinese)刘凯,王革非,吴性江,等.水通道蛋白在肝胆系统中的生理学研究进展[J].肠外与肠内营养,2012,5(19):316-318.
    [14]LAKNER AM,WALLING TL,MCKILLOP IH,et al.Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation[J].Liver Int,2011,31(1):42-51.
    [15]CARRERAS FI,LEHMANN GL,FERRI D,et al.Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis[J].Am JPhysiol Gastrointest Liver Physiol,2007,292(3):905-912.
    [16]van ERPECUM KJ,WANG DQ,MOSCHETTA A,et al.Gallbladder histopathology during murine gallstone formation:relation to motility and concentrating function[J].J Lipid Res,2006,47(1):32-41.
    [17]IGUCHI H,ODA M,YAMAZAKI H,et al.Aquaporin-1 is associated with arterial capillary proliferation and hepatic sinusoidal transformation contributing to portal hypertension in primary biliary cirrhosis[J].Med Mol Morphol,2014,47(2):90-99.
    [18]MOBASHERI A,MARPLES D.Expression of the AQP-1 water channel in normal human tissues:a semiquantitative study using tissue microarray technology[J].Am J Physiol Cell Physiol,2004,286(3):c529-c537.
    [19]HUEBERT RC,VASDEV MM,SHERGILL U,et al.Aquaporin-1facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis[J].Hepatology,2010,52(1):238-248.
    [20]ECHEVARRIA M,MUNOZ-CABELLO AM,SANCHEZ-SILVA R,et al.Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression[J].J Biol Chem,2007,822(41):30207-30215.
    [21]REESE J,DAS SK,PARIA BC,et al.Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation[J].J Biol Chem,2001,276(47):44137-44145.
    [22]RUBANYI GM,JOHNS A,KAUSER K.Effect of estrogen on endothelial function and angiogenesis[J].Vascul Pharmacol,2002,38(2):89-98.
    [23]CORTEZ-PINTO H,BAPTISTA A,CAMILO ME,et al.Nonalcoholic steatohepatitis---long-term follow-up study:comparison with alcoholic hepatitis in ambulatory and hospitalized patients[J].Dig Dis Sci,2003,48(10):1909-1913.
    [24]ROJEK AM,SKOWRONSKI MT,FUCHTBAUER EM,et al.Defective glycerol metabolism in aquaporin 9(AQP9)knockout mice[J].Proc Natl Acad Sci U S A,2007,104(9):3609-3614.
    [25]CARBREY JM,GORELICK-FELDMAN DA,KOZONO D,et al.Aquaglyceroporin AQP9:solute permeation and metabolic control of expression in liver[J].Proc Natl Acad Sci U S A,2003,100(5):2945-2950.
    [26]HARA-CHIKUMA M,SOHARA E,RAI T,et al.Progressive adipocyte hypertrophy in aquaporin-7-deficient mice:adipocyte glycerol permeability as a novel regulator of fat accumulation[J].JBiol Chem,2005,280(16):15493-15496.
    [27]QIU LW,GU LY,LYU L,et al.Expression of aquaglyceroporins in nonalcoholic hepatocyte steatosis and its significance[J].J Third Milit Med Univ,2012,34(7):622-626.(in Chinese)邱烈旺,顾陆昀,吕琳,等.水甘油通道蛋白在非酒精性脂肪变性肝细胞模型中的表达及意义[J].第三军医大学学报,2012,34(7):622-626.
    [28]CHIAPPINI F,BARRIER A,SAFFROY R,et al.Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray[J].Lab Invest,2006,86(2):154-165.
    [29]ROSENGREN S,HENSON PM,WORTHEN GS.Migration-associated volume changes in neutrophils facilitate the migratory process in vitro[J].Am J Physiol,1994,267(6 Pt 1):c1623-c1632.
    [30]HUEBERT RC,JAGAVELU K,HENDRICKSON HI,et al.Aquaporin-1 promotes angiogenesis,fibrosis,and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs[J].Am JPathol,2011,179(4):1851-1860.
    [31]ESTEVA-FONT C,BACCARO ME,FERNANDEZ-LLAMA P,et al.Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis:relationship with ascites and hepatorenal syndrome[J].Hepatology,2006,44(6):1555-1563.
    [32]JONASSEN TE,CHRISTENSEN S,KWON TH,et al.Renal water handing in rats with decompensated liver cirrhosis[J].Am J Physiol Renal Physiol,2000,279(6):f1101-f1109.
    [33]GEILSWIJK M,THOMSEN KL,PEDERSEN EB,et al.Urinary aquaporin-2 excretion before and after transjugular intrahepatic portosystemic shunt insertion for refractory ascites[J].Scand J Gastroenterol,2015,50(4):454-461.
    [34]AGGARWAL S,KRAMER D,YONAS H,et al.Cerebral hemodynamic and metabolic changes in fulminant hepatic failure:a retrospective study[J].Hepatology,1994,19(1):80-87.
    [35]RAMA RAO KV,CHEN M,SIMARD JM,et al.Increased aquaporin-4 expression in ammonia-treated cultured astrocytes[J].Neuroreport,2003,14(18):2379-2382.
    [36]RAMA RAO KV,NORENBERG MD.Aquaporin-4 in hepatic encephalopathy[J].Metab Brain Dis,2007,22(3-4):265-275.
    [37]MONZANI E,BAZZOTTI R,PEREGO C,et al.AQP1 is not only a water channel:it contributes to cell migration through Lin7/beta-catenin[J].PLo S One,2009,4(7):e6167.
    [38]IWAKIRI Y.Endothelial dysfunction in the regulation of cirrhosis and portal hypertension[J].Liver Int,2012,32(2):199-213.
    [39]KANEKO K,YAGUI K,TANAKA A,et al.Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells[J].Microvasc Res,2008,75(3):297-301.
    [40]CLAPP C,MARTINEZ de la ESCALERA G.Aquaporin-1:a novel promoter of tumor angiogenesis[J].Trends Endocrinol Metab,2006,17(1):1-2.
    [41]GARCIA F,KIERBEL A,LAROCCA MC,et al.The water channel aquaporin-8 is mainly intracellular in rat hepatocytes,and its plasma membrane insertion is stimulated by cyclic AMP[J].J Biol Chem,2001,276(15):12147-12152.
    [42]RIBATTI D,RANIERI G,ANNESE T,et al.Aquaporins in cancer[J].Biochim Biophys Acta,2014,1840(5):1550-1553.
    [43]HUBER VJ,TSUJITA M,NAKADA T.Aquaporins in drug discovery and pharmacotherapy[J].Mol Aspects Med,2012,33(5-6):691-703.
    [44]HUBER VJ,TSUJITA M,NAKADA T.Identification of aquaporin4 inhibitors using in vitro and in silico methods[J].Bioorg Med Chem,2009,17(1):411-417.
    [45]MA B,XIANG Y,MU SM,et al.Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected xenopus oocyte[J].Acta Pharmacol Sin,2004,25(1):90-97.
    [46]MIGLIATI E,MEURICE N,DUBOIS P,et al.Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site[J].Mol Pharmacol,2009,76(1):105-112.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2004) PDF downloads(441) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return