Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances

Rutao LIN; Fei XU; Xin XIN; Yiyang HU; Qin FENG

doi:10.12449/JCH260426

Volume 42 Issue 4

Apr. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(4): 950-956

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Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances

DOI: 10.12449/JCH260426

Rutao LIN^{1, 2, 3},
Fei XU^{1, 2, 3},
Xin XIN^{1, 2, 3},
Yiyang HU^{1, 2, 3, 4
,
,
,},
Qin FENG^{1, 2, 3
,
,
,}

1.
Institute of Liver Diseases，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
2.
Institute of Liver Diseases，Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
3.
Key Laboratory of Liver and Kidney Diseases，Ministry of Education，Shanghai 201203，China
4.
Clinical Research Center，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China

Research funding:

General Project of National Natural Science Foundation of China (82174040);

General Project of National Natural Science Foundation of China (82174186);

Shanghai Sailing Program (23YF1448200);

National Administration of Traditional Chinese Medicine (zyyzdxk-2023060);

Shanghai Oriental Talent Top-notch Program (BJWS2025018)

More Information

Corresponding author: HU Yiyang， yyhuliver@163.com （ORCID： 0000-0001-9127-7002）; FENG Qin， fengqin@shutcm.edu.cn （ORCID： 0000-0002-4641-1636）
Received Date: 2025-08-12
Accepted Date: 2025-09-12
Published Date: 2026-04-25

Abstract

Abstract

In 2023， multiple international societies proposed the concept of metabolic-dysfunction and alcohol-associated liver disease （MetALD） to characterize patients with steatotic liver disease who exhibit metabolic dysfunction and consume alcohol at a moderate level. In recent years， the evidence system in this field has been constantly developed and improved. This article reviews the latest research advances in MetALD from the aspects of background， definition， epidemiological characteristics， natural history， clinical phenotype， diagnostic and assessment methods， and treatment regimens， as well as the directions for future investigation.

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References(55)

References

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Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances

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Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances

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