Metabolic dysfunction-associated fatty liver disease with different clinical phenotypes： Pathogenesis and strategies for integrated traditional Chinese and Western medicine treatment

Wenxia ZHAO; Lei GAO; Xinju CHEN; Yuanyuan ZHENG; Sutong LIU; Lihui ZHANG; Qing ZHAO; Chenlu ZHAO

doi:10.12449/JCH260423

Volume 42 Issue 4

Apr. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(4): 930-937

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Metabolic dysfunction-associated fatty liver disease with different clinical phenotypes： Pathogenesis and strategies for integrated traditional Chinese and Western medicine treatment

DOI: 10.12449/JCH260423

Wenxia ZHAO^{1, 2, 3
,
,
,},
Lei GAO^{4
,
,
,},
Xinju CHEN¹,
Yuanyuan ZHENG¹,
Sutong LIU^{1, 2, 3},
Lihui ZHANG^{1, 2, 3},
Qing ZHAO^{1, 2, 3},
Chenlu ZHAO^{1, 2, 3}

1.
Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
Research Institute of National Famous Traditional Chinese Medicine Expert Zhao Wenxia，Henan Academy of Chinese Medicine Sciences，Zhengzhou 450000，China
3.
Henan Province Collaborative Innovation Center for Prevention and Treatment of Major Diseases by Chinese and Western Medicine，Zhengzhou 450000，China
4.
School of Basic Medical Sciences，Guangzhou University of Chinese Medicine，Guangzhou 510006，China

Research funding:

National Natural Science Foundation of China (82205086);

National Famous Traditional Chinese Medicine Inheritance Studio Construction Project (National Medical Affairs Office, Renjiaohan ［2022］ No.245);

Independent Project of National Science and Technology Major Project (2018ZX1030502)

More Information

Corresponding author: ZHAO Wenxia， zhao-wenxia@163.com （ORCID： 0000-0002-0592-3504）; GAO Lei， raygaolei@smu.edu.cn （ORCID： 0000-0001-9030-390X）
Received Date: 2025-12-31
Accepted Date: 2026-01-19
Published Date: 2026-04-25

Abstract

Abstract

Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic metabolic liver disorder with complex etiologies. Different clinical phenotypes of MAFLD （such as obesity， hyperlipidemia， type 2 diabetes mellitus， the postmenopausal state， and chronic hepatitis B） have different mechanisms of action in the development and progression of MAFLD， leading to high heterogeneity in its clinical progression and prognosis. This article systematically reviews the pathogeneses and clinical features of the above five clinical phenotypes of MAFLD and elaborates on the corresponding individualized diagnosis and treatment regimens integrating traditional Chinese medicine and Western medicine， in order to provide a reference for clinical practice and improve clinical diagnosis and treatment.
- Metabolic Dysfunction-Associated Fatty Liver Disease,
- Obesity,
- Hyperlipidemias,
- Diabetes Mellitus， Type 2,
- Postmenopause,
- Hepatitis B， Chronic

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References(56)

References

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Metabolic dysfunction-associated fatty liver disease with different clinical phenotypes： Pathogenesis and strategies for integrated traditional Chinese and Western medicine treatment

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