Application of serum markers in early diagnosis of acute cholangitis

Yu PENG; Yujie CHEN; Wei LI; Qingming WU; Weitian XU; Kai GUO

doi:10.12449/JCH260232

Volume 42 Issue 2

Feb. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(2): 479-483

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Application of serum markers in early diagnosis of acute cholangitis

DOI: 10.12449/JCH260232

Yu PENG^{1, 2},
Yujie CHEN^{1, 2},
Wei LI^{1, 2},
Qingming WU¹,
Weitian XU²,
Kai GUO^{2
,
,
,}

1.
School of Medicine，Wuhan University of Science and Technology，Wuhan 430081，China
2.
Department of Gastroenterology，General Hospital of Central Theater Command of the People's Liberation Army of China，Wuhan 430070，China

Research funding:

Hubei Provincial Natural Science Foundation Guiding Project (2023AFC039);

Wuhan Knowledge Innovation Special Project (2023020201010180);

Hubei Provincial Key Laboratory (ZZYKF202102)

More Information

Corresponding author: GUO Kai， gkai202411@163.com （ORCID： 0000-0003-3904-680X）
Received Date: 2025-06-10
Accepted Date: 2025-08-29
Published Date: 2026-02-25

Abstract

Abstract

Acute cholangitis （AC） is a common acute abdominal disease in clinical practice， and the early accurate diagnosis of AC is of great importance for improving prognosis； however， traditional diagnostic methods are limited by insufficient sensitivity and specificity. This article systematically reviews the value of traditional serum markers （such as neutrophil-to-lymphocyte ratio， procalcitonin， and C-reactive protein） and their combination in the early diagnosis of AC， with a focus on the research advances and potential application value of novel biomarkers for infection and inflammation， including presepsin， soluble triggering receptor expressed on myeloid cells-1， lipocalin 2， high-mobility group protein B1， and intestinal fatty acid-binding protein 1. At present， the combination of multiple biomarkers and dynamic monitoring of novel markers are key strategies for enhancing the early diagnosis and risk stratification of AC. Future research should focus on the integration of novel and traditional serum markers and the construction of comprehensive predictive models， in order to promote the establishment of a standardized system for the early diagnosis of AC.
- Cholangitis,
- Biomarkers,
- Early Diagnosis

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References(33)

References

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Application of serum markers in early diagnosis of acute cholangitis

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