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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 42 Issue 1
Jan.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(1): 235-240

Association between ectopically colonized oral bacteria and chronic liver disease

DOI: 10.12449/JCH260131
  • 1.

    College of Traditional Chinese Medicine，Hubei University of Chinese Medicine，Wuhan 430065，China

  • 2.

    Institute of Liver Diseases，Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine，Hubei Provincial Hospital of Traditional Chinese Medicine，Clinical Research Center for TCM liver Diseases，Wuhan 430061，China

  • 3.

    Guang’anmen Hospital，China Academy of Chinese Medical Sciences，Institute of Metabolic Diseases，Beijing 100053，China

  • 4.

    The Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

Research funding:

National Natural Science Foundation of China （General Program） (82274352);

Natural Science Foundation of Hubei Province (2020CFA023);

Natural Science Foundation of Hubei Province (2023AFB426);

Natural Science Foundation of Hubei Province (2023AFD129);

Natural Science Foundation of Hubei Province (2023AFD178)

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  • Corresponding author: LI Xiaodong， lixiaodong555@126.com （ORCID： 0000-0002-6406-9416）
  • Received Date: 2025-05-28
  • Accepted Date: 2025-07-22
  • Published Date: 2026-01-25
    Abstract
  • Chronic liver disease is a general term for a variety of liver diseases， and its prevalence rate is increasing year by year. With the progression of the disease， patients may experience a variety of serious complications and even progress to liver failure. In recent years， a number of studies have revealed the association between ectopically colonized oral bacteria and chronic liver disease and explored their potential value in the diagnosis and treatment of chronic liver disease. This article systematically reviews the association of ectopically colonized oral bacteria with metabolic associated fatty liver disease， liver cirrhosis， and liver cancer and analyzes the mechanism for the influence of ectopically colonized oral bacteria on chronic liver disease， so as to provide a reference for the diagnosis and treatment of chronic liver disease using ectopically colonized oral bacteria.

     

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