Clinical features and management of liver cirrhosis comorbid with severe acute respiratory syndrome coronavirus 2 infection

Wenli JIANG; Wenlong YANG; Lei LUO

doi:10.12449/JCH260126

Volume 42 Issue 1

Jan. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(1): 203-208

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Clinical features and management of liver cirrhosis comorbid with severe acute respiratory syndrome coronavirus 2 infection

DOI: 10.12449/JCH260126

Department of Infectious Diseases，The Second Affiliated Hospital of Nanchang University，Nanchang 330006，China

Research funding:

Doctoral Start-up Fund of the Second Affiliated Hospital of Nanchang University (B2273);

Clinical Research Special Fund of Beijing iGandan Foundation (iGandanF-1082024-LG009);

Artificial Liver Special Fund of Beijing iGandan Foundation (RGGJJ-2021-028)

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Corresponding author: YANG Wenlong， wenlooyang@163.com （ORCID： 0000-0003-3756-7468）; LUO Lei， zgll1990@163.com （ORCID： 0000-0002-7999-9560）
Received Date: 2025-04-01
Accepted Date: 2025-05-13
Published Date: 2026-01-25

Abstract

Abstract

Patients with liver cirrhosis are more susceptible to various bacterial or viral infections due to immune dysfunction. Recent studies have shown that compared with the general population， individuals with liver cirrhosis show a significant increase in the incidence rate of adverse outcomes after severe acute respiratory syndrome coronavirus 2 infection， including the progression of liver injury and the increase in mortality rate. Vaccination can reduce the incidence rates of breakthrough infections and severe coronavirus disease 2019 （COVID-19） in patients with liver cirrhosis， but such patients have low immune response and thus require booster doses to enhance immunity. This article reviews the clinical features of cirrhotic patients with COVID-19 and related management strategies， in order to provide evidence-based guidance for the clinical diagnosis and treatment of such patients.
- Liver Cirrhosis,
- COVID-19,
- COVID-19 Vaccines,
- Clinical Governance

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References(42)

References

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Clinical features and management of liver cirrhosis comorbid with severe acute respiratory syndrome coronavirus 2 infection

DOI: 10.12449/JCH260126

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Clinical features and management of liver cirrhosis comorbid with severe acute respiratory syndrome coronavirus 2 infection

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