Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

Yudie HONG; Jinchen GUO; Weibing SHI; Yujie SUN; Jiamin WANG; Tiantian GAO

doi:10.12449/JCH260124

Volume 42 Issue 1

Jan. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(1): 190-196

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Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

DOI: 10.12449/JCH260124

1.
Department of Hepatology，The First Affiliated Hospital School of Anhui University of Chinese Medicine，Hefei 230031，China
2.
College of Traditional Chinese Medicine，Anhui University of Chinese Medicine，Hefei 230012，China

Research funding:

Key Scientific Research Projects of Higher Education Institutions of Anhui Provincial Department of Education (2023AH050733);

Key Scientific Research Projects of Higher Education Institutions of Anhui Provincial Department of Education (2023AH050783);

Key Cultivation Project of Xin’an Medical and Traditional Chinese Medicine Modernization Research Institute of Hefei Comprehensive National Science Center Big Health Research Institute (2023CXMMTCM009)

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Corresponding author: SHI Weibing， swbsxj@163.com （ORCID： 0009-0000-8547-136X）
Received Date: 2025-05-21
Accepted Date: 2025-07-04
Published Date: 2026-01-25

Abstract

Abstract

Hepatic fibrosis refers to excessive accumulation and abnormal proliferation of fibrous connective tissue in the liver triggered by multiple pathogenic factors， and it may progress to liver cirrhosis， portal hypertension， and liver cancer. The pathological mechanisms of hepatic fibrosis involve hepatocyte injury， inflammatory cell infiltration with the release of inflammatory mediators， hepatic stellate cell activation， and extracellular matrix deposition. Recent studies have focused on mitochondrial dysfunction in disease progression， including the molecular pathways for hepatic fibrosis driven by metabolic disorders， energy deficiency， oxidative stress， mitochondrial dynamic imbalance， and autophagic dysfunction， all of which can induce liver injury. This article reviews the latest advances in hepatic fibrosis， in order to provide new therapeutic strategies for clinical management.
- Hepatic Fibrosis,
- Mitochondria,
- Pathologic Processes

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References

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Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

DOI: 10.12449/JCH260124

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Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

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