Role and mechanism of myeloid cells in hepatic fibrosis

Chengjie CUI; Zhenzhen ZHAO; Jing CUI; Shuxian ZANG; Na FU

doi:10.12449/JCH260123

Volume 42 Issue 1

Jan. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(1): 183-189

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Role and mechanism of myeloid cells in hepatic fibrosis

DOI: 10.12449/JCH260123

Department of Traditional and Western Medical Hepatology，Third Hospital of Hebei Medical University，Shijiazhuang 050051，China

Research funding:

Cultivation Project of Precision Medicine Joint Fund of Natural Science Foundation of Hebei Province (H2025206096);

Government Funded Project for Outstanding Talents in Clinical Medicine (ZF2024072);

Hebei Province Traditional Chinese Medicine Scientific Research Project Plan (2025320)

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Corresponding author: FU Na， 38200273@hebmu.edu.cn （ORCID： 0009-0006-2071-6307）
Received Date: 2025-05-18
Accepted Date: 2025-07-01
Published Date: 2026-01-25

Abstract

Abstract

Hepatic fibrosis is a complex dynamic process caused by multiple chronic pathogenic factors， characterized by excessive accumulation of liver extracellular matrix and abnormal liver structure and function. If anti-fibrotic treatment is not performed in time， it can progress to liver cirrhosis and even liver cancer. Hepatic fibrosis has a complex pathogenesis， and previous studies mainly focused on the activation of hepatic stellate cells. Recent studies have shown that myeloid cells have the potential of multi-directional differentiation and can also participate in the development and progression of hepatic fibrosis. This article systematically reviews the role and regulatory mechanism of myeloid cells in hepatic fibrosis， in order to provide a reference for clinical diagnosis and targeted therapy.
- Hepatic Fibrosis,
- Myeloid Cells,
- Mechanism

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References

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Role and mechanism of myeloid cells in hepatic fibrosis

DOI: 10.12449/JCH260123

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Role and mechanism of myeloid cells in hepatic fibrosis

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