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Volume 41 Issue 12
Dec.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(12): 2581-2585

Association between corneal Kayser-Fleischer ring grading and the degree of anxiety-depression in patients with Wilson’s disease

DOI: 10.12449/JCH251220

  • Department of Ophthalmology，The First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230001，China

Research funding:

National Natural Science Foundation of China（Joint Fund for Regional Innovation and Development） (U22A20366)

More Information
  • Corresponding author: CHEN Yi， chenyi@azyfy.com （ORCID： 0009-0004-4568-9144）
  • Received Date: 2025-07-14
  • Accepted Date: 2025-09-11
  • Published Date: 2025-12-25
    Abstract
  •   Objective  To investigate the impact of different grades of corneal Kayser-Fleischer （K-F） ring on the severity of anxiety and depression in patients with Wilson’s disease （WD）.  Methods  A total of 107 patients with WD who received consultation in Department of Ophthalmology， The First Affiliated Hospital of Anhui University of Chinese Medicine， from August 2012 to February 2020 were enrolled， and a slit-lamp microscope was used to determine the grade of corneal K-F ring （grades 0 — 4）. The patients were instructed to complete Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale （HAMD） assessments， and the correlation between K-F ring grade and the scores of the two scales was analyzed， as well as the differences in the scores of the two scales between the patients with different K-F ring grades. An analysis of variance was used for comparison of normally distributed continuous data between multiple groups， and the least significant difference t-test or the Dunnett’s T3 test was used for further comparison between two groups； the Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data between multiple groups， and the Bonferroni method was used for further comparison between two groups. The Spearman correlation analysis was used to investigate the correlation between K-F ring grade and HAMA/HAMD score.  Results  Among the 107 patients with WD， the patients with grade 0 K-F ring accounted for the lowest proportion of 4.6% （5/107）， while the patients with grade 4 K-F ring accounted for the highest proportion of 41.1% （44/107）， and the patients with grade 1 K-F ring， grade 2 K-F ring， and grade 3 K-F ring accounted for 16.8% （18/107）， 22.4% （24/107）， and 14.9% （16/107）， respectively. HAMA and HAMD scores tended to increase with the increase in K-F ring grade （F=16.340 and 12.760， both P <0.001）. The Spearman correlation analysis showed that K-F ring grade was positively correlated with HAMA and HAMD scores （r=0.528 9 and 0.480 1， both P<0.01）.  Conclusion  There is a certain correlation between corneal K-F ring grading and HAMD/HAMA scores， which can partially reflect the severity of anxiety and depression in patients. Therefore， clinicians should emphasize K-F ring examination and its association with clinical symptoms.

     

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