Features and risk factors in chronic hepatitis B patients comorbid with metabolic associated fatty liver disease

Qing ZHAO; Lihui ZHANG; Sutong LIU; Dongfang SHANG; Qiang ZHANG; Wenxia ZHAO

doi:10.12449/JCH251212

Volume 41 Issue 12

Dec. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(12): 2512-2519

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Features and risk factors in chronic hepatitis B patients comorbid with metabolic associated fatty liver disease

DOI: 10.12449/JCH251212

1.
Department of Gastroenterology，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450000，China

Research funding:

National Natural Science Foundation of China Youth Science Foundation Project (82205086);

National Famous Traditional Chinese Medicine Inheritance Studio Construction Project (Chinese Medicine Office Human Education Letter ［2022］ 245);

Special Subject of Scientific Research on Traditional Chinese Medicine in Henan Province (2022JDZX031);

Special Subject of Scientific Research on Traditional Chinese Medicine in Henan Province (2023ZXZX1092)

More Information

Corresponding author: ZHAO Wenxia， zhao-wenxia@163.com （ORCID： 0000-0001-6666-9469）
Received Date: 2025-07-07
Accepted Date: 2025-08-08
Published Date: 2025-12-25

Abstract

Abstract

Objective To investigate the comorbidity features of chronic hepatitis B （CHB） patients comorbid with metabolic associated fatty liver disease （MAFLD）， to analyze its risk factors， and to provide a basis for clinical prevention and treatment. Methods A total of 92 patients who were diagnosed with CHB in The First Affiliated Hospital of Henan University of Chinese Medicine from January 2023 to December 2024 were enrolled and divided into CHB+MAFLD group with 52 patients and CHB group with 40 patients. Related data were collected from all patients， including general information， medical history， serum biochemical parameters， virological testing indicators， and FibroScan results. The independent-samples t test or the Mann-Whitney U test was used for comparison of continuous data between two groups； the chi-square test or the Fisher’s exact test was used for comparison of categorical data between two groups； the binary Logistic regression analysis was used to investigate the risk factors for CHB comorbid with MAFLD. Results There were significant differences between the two groups in sex， body mass index （BMI）， antiviral therapy， duration of antiviral medication， the preference for high-fat diet or spicy foods， and the levels of alanine aminotransferase， uric acid （UA）， triglyceride （TG）， high-density lipoprotein cholesterol， and controlled attenuation parameter （all P<0.05）. The univariate regression analysis showed that male sex， preference for high-fat diet and spicy foods， antiviral therapy， antiviral medication for >5 years， BMI ≥24 kg/m²， UA >357 μmol/L， and TG >1.70 mmol/L were associated with comorbidity with MAFLD （all P <0.05）； the multivariate regression analysis showed that antiviral medication >5 years （odds ratio ［OR］=9.38， 95% confidence interval ［CI］： 2.28 — 38.60， P=0.002）， BMI ≥24 kg/m² （OR=5.60， 95%CI： 1.75 — 17.88， P=0.004）， and TG >1.70 mmol/L （OR=4.08， 95%CI： 1.17 — 14.31， P=0.028） were independent risk factors for CHB patients comorbid with MAFLD. Conclusion CHB comorbid with MAFLD is the result of metabolic disorders and long-term antiviral therapy. Clinical management should be enhanced for CHB patients with long-term antiviral therapy， overweight/obesity， and hypertriglyceridemia， and targeted screening and intervention strategies should be implemented.
- Hepatitis B， Chronic,
- Metabolic Associated Fatty Liver Disease,
- Multiple Chronic Conditions,
- Risk Factors

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Features and risk factors in chronic hepatitis B patients comorbid with metabolic associated fatty liver disease

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