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Volume 41 Issue 11
Nov.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(11): 2435-2440

The role and mechanism of heparanase in hepatobiliary and pancreatic tumors

DOI: 10.12449/JCH251136
  • 1.

    The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China

  • 2.

    Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China

  • 3.

    Department of Gastroenterology，The Fifth People’s Hospital of Ganzhou，Ganzhou，Jiangxi 341000，China

Research funding:

Gansu Province Health and Wellness Industry Research Plan Project (GSWSKY2023-34);

Gansu University of Chinese Medicine Supervisor Special Project (2023YXKY020);

Lanzhou City Youth Science and Technology Talent Innovation Project (2024-QN-39)

More Information
  • Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）; LIANG Bin， 123450632@qq.com （ORCID： 0000-0003-4427-8445）
  • Received Date: 2025-03-17
  • Accepted Date: 2025-05-12
  • Published Date: 2025-11-25
    Abstract
  • Hepatobiliary and pancreatic tumors are common types of digestive system disorders， and their complex pathogeneses have led to difficulties in early diagnosis and a high metastasis rate， with persistently high incidence and mortality rates in China， which greatly affects the quality of life and prognosis of patients. Studies have shown that heparanase （HPSE）， as a key effector molecule in matrix remodeling， plays a crucial regulatory role in tumor invasion and metastasis and microenvironment remodeling， and it is significantly associated with clinical prognosis. This article reviews the molecular mechanism of HPSE in hepatobiliary and pancreatic tumors， in order to provide a strong scientific basis for developing diagnostic markers and targeted interventions for hepatobiliary and pancreatic tumors.

     

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