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CN 22-1108/R
Volume 41 Issue 11
Nov.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(11): 2410-2417

Role of neutrophil extracellular traps in hepatocellular carcinoma

DOI: 10.12449/JCH251132
  • 1.

    Graduate School，Guangxi University of Chinese Medicine，Nanning 530020，China

  • 2.

    Guangxi University Engineering Research Center for Innovative Product Development of Regional Major Diseases，Guangxi University of Chinese Medicine，Nanning 530020，China

  • 3.

    Department of Internal Medicine，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

  • 4.

    First Ward of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (U23A20521);

Yao Chun Gui School of Traditional Chinese Medicine Masters Inheritance Workshop (GZY2024002);

Guangxi Traditional Chinese Medicine Tongyang Dissipation Method Key Research Laboratory Project ;

Guangxi Multidisciplinary Interdisciplinary Cross-Innovation Team of Traditional Chinese Medicine, Zhuang and Yao Medicines (GZKJ2301);

Guangxi Traditional Chinese Medicine Diagnostics and Treatment of Difficult and Serious Diseases Research Team (2022A001);

National Administration of Traditional Chinese Medicine High-level Traditional Chinese Medicine Key Discipline Construction Project-Traditional Chinese Medicine Internal Science (zyyzdxk-2023166);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025050);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCBZ2024149);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025051);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025056)

More Information
  • Corresponding author: YAO Chun， yaoc@gxtcmu.edu.cn （ORCID： 0000-0003-2903-8814）
  • Received Date: 2025-04-01
  • Accepted Date: 2025-04-25
  • Published Date: 2025-11-25
    Abstract
  • Hepatocellular carcinoma （HCC） is a malignant tumor with high incidence and mortality rates worldwide. Recent studies have shown that neutrophil extracellular traps （NETs） play an important role in the development， progression， and immune escape of HCC. NETs are released by neutrophils and mainly consist of DNA， histones， and antimicrobial molecules， and in addition to immune defense， they are also involved in the initiation， metastasis， and thrombosis of HCC. This article elaborates on the formation and regulatory mechanisms of NETs， explores their potential mechanisms in the initiation， metastasis， immune escape， and thrombosis of HCC， and discusses the prospect of NETs as a target for the diagnosis and treatment of HCC， in order to provide new ideas for the precise treatment of HCC in the future and promote the early diagnosis and effective treatment of HCC.

     

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