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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 11
Nov.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(11): 2365-2371

Influence of NOD-like receptor protein 3 inflammasome on the development and progression of nonalcoholic steatohepatitis and the interventional effect of traditional Chinese medicine

DOI: 10.12449/JCH251125
  • 1.

    School of Integrated Traditional Chinese and Western Medicine，Gansu University of Chinese Medicine，Lanzhou 730000，China

  • 2.

    Department of Spleen and Stomach Diseases，The Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730000，China

  • 3.

    Pediatric Emergency Center Branch II，Gansu Provincial Central Hospital，Lanzhou 730000，China

Research funding:

Young Qihuang Scholars Fund Project (［2022］ No. 256);

Key Project of Gansu Provincial Administration of Traditional Chinese Medicine (GZKZ-2021-6);

Key Research and Development Program of Gansu Provincial Department of Science and Technology (22YFTFA100);

Innovation Base and Talent Program of Gansu Provincial Department of Science and Technology (21JR7RA682);

Provincial Key Talent Project and Longyuan Young Innovation Entrepreneurship Talent Project (2022RCXM020)

More Information
  • Corresponding author: LIU Junhong， lhz8686@163.com （ORCID： 0000-0002-5784-5296）
  • Received Date: 2025-04-01
  • Accepted Date: 2025-05-19
  • Published Date: 2025-11-25
    Abstract
  • Nonalcoholic steatohepatitis （NASH） is a chronic liver disease with the main pathological features of hepatic steatosis， inflammatory cell infiltration， and interstitial fibroplasia， and it is an important risk factor for liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. NOD-like receptor protein 3 （NLRP3） inflammasome is the core of innate immunity， and the abnormal activation of NLRP3 inflammasome is closely associated with the development and progression of NASH， which involves multiple links such as inflammatory response and oxidative stress. A large number of studies have shown that the active ingredients of traditional Chinese medicine （TCM） and TCM compound prescriptions can improve oxidative stress， regulate lipid metabolism， and alleviate liver inflammation by regulating NLRP3 inflammasome. TCM treatment applied in clinical practice has achieved a good therapeutic effect， while inflammasome is one of the key pathways or targets for TCM in improving NASH. This article reviews the mechanism of action of NLRP3 inflammasome in NASH and the research advances in TCM intervention of NLRP3 inflammasome， in order to provide ideas for the clinical TCM treatment of NASH， as well as reference targets and research directions for the research and development of new TCM drugs.

     

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    The first journal specializing in hepatobiliary and pancreatic diseases in China

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