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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 11
Nov.  2025
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Article Contents

Metabolic and alcohol-associated liver disease: A novel liver disease entity

DOI: 10.12449/JCH251106
Research funding:

National Natural Science Foundation of China (U24A20654);

National Natural Science Foundation of China (82170602);

Natural Science Foundation for Self-exploration Research of Jilin Province (YDZJ202401427ZYTS);

Jilin Provincial Key Laboratory of Metabolic Liver Diseases (YDZJ202502CXJD002)

More Information
  • Corresponding author: GAO Yanhang, yanhang@mail.jlu.edu.cn (ORCID: 0000-0001-8590-6706)
  • Received Date: 2025-09-16
  • Accepted Date: 2025-10-13
  • Published Date: 2025-11-25
  • The term “metabolic and alcohol-related liver disease (MetALD)” recently proposed emphasizes the synergistic role of metabolic dysfunction and alcohol exposure in the progression of liver injury. Although this theoretical framework improves the understanding of the multifactorial and complex nature of liver disease, its clinical application still faces numerous new challenges in diagnosis and treatment. This article summarizes the latest evidence for the prevalence, potential pathogenesis, clinical diagnostic markers, and treatment of MetALD and particularly emphasizes the urgency to develop reliable preclinical models that can accurately simulate the intricate pathophysiology of this disease due to various factors. This article also provides a systematic evaluation of emerging therapies including fecal microbiota transplantation and nutritional interventions and proposes the future directions for drug innovation in MetALD.

     

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