Research advances in the mechanisms of increased susceptibility to sepsis in alcoholic liver disease

Hang LIU; Yan GUO

doi:10.12449/JCH250829

Volume 41 Issue 8

Aug. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(8): 1662-1667

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Research advances in the mechanisms of increased susceptibility to sepsis in alcoholic liver disease

DOI: 10.12449/JCH250829

Hang LIU¹,
Yan GUO^{2
,
,
,}

1.
The First Clinical College of Shanxi Medical University，Taiyuan 030001，China
2.
Department of Critical Care Medicine，The First Hospital of Shanxi Medical University，Taiyuan 030001，China

Research funding:

Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province (20240045)

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Corresponding author: GUO Yan， 2008guoyan@sina.com （ORCID： 0009-0003-9176-0637）
Received Date: 2025-01-05
Accepted Date: 2025-03-10
Published Date: 2025-08-25

Abstract

Abstract

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection， and currently there is still a lack of effective therapies. Alcoholic liver disease （ALD） is the most important cause of death caused by alcohol in Western countries， and sepsis is one of the most common complications and causes of death in ALD. This article reviews the research advances in the mechanism by which ALD increases the susceptibility to sepsis， in order to provide a reference for the prevention and treatment of sepsis in ALD patients.
- Sepsis,
- Alcoholic Liver Disease,
- Immune System,
- Gastrointestinal Microbiome

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References(53)

References

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Research advances in the mechanisms of increased susceptibility to sepsis in alcoholic liver disease

DOI: 10.12449/JCH250829

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Research advances in the mechanisms of increased susceptibility to sepsis in alcoholic liver disease

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