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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 4
Apr.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(4): 748-754

The mechanism and clinical application value of interleukin-10 family in anti-hepatic fibrosis

DOI: 10.12449/JCH250422
  • 1.

    Graduate School of Guangxi University of Chinese Medicine，Nanning 530200，China

  • 2.

    Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530200，China

  • 3.

    Department of Science and Technology，Guangxi University of Chinese Medicine，Nanning 530200，China

Research funding:

Guangxi Key Research and Development Programme Project (GuiKe AB22035076);

the Seventh Batch of National Old Chinese Medicine Experts Academic Experience Inheritance Work Project (GZY2024002);

2023 Guangxi Chinese Medicine Multidisciplinary Cross-Innovation Team (GZKJ2301);

Guangxi University of Traditional Chinese Medicine ‘Gui school of traditional Chinese Medicine Inheritance and Innovation Team’ Class a Funding Project (2022A001);

Guangxi Key Research Laboratory Project of Traditional Chinese Medicine Tong Yang Dispersal Method ;

State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Program of Traditional Chinese Medicine-Internal Medicine of Traditional Chinese Medicine (zyyzdxk-2023166)

More Information
  • Corresponding author: YAO Chun， yaochun111@163.com （ORCID： 0000-0003-2903-8814）
  • Received Date: 2024-08-21
  • Accepted Date: 2024-09-26
  • Published Date: 2025-04-25
    Abstract
  • The interleukin-10 （IL-10） family is expressed in various types of cells and has a wide range of biological functions， and it plays an important role in the development and progression of hepatic fibrosis. Hepatic fibrosis is a chronic liver disease characterized by abnormal repair of hepatic tissues after injury， activation of hepatic stellate cells， and excessive accumulation of extracellular matrix. The IL-10 family members include IL-10， IL-19， IL-20， IL-22， IL-24， IL-26， IL-28， IL-29， and IL-35， with similarities in structure and function， and changes in their expression levels are closely associated with the progression of hepatic fibrosis. Moderate upregulation of the expression of IL-10 family members can help maintain the quiescent state of hepatic stellate cells， promote the transformation of macrophages to anti-inflammatory phenotype， and regulate the activity of natural killer cells， thereby inhibiting inflammatory response， regulating cell apoptosis and autophagy， and finally reversing the progression of hepatic fibrosis. This article discusses the mechanism of action of IL-10 family members and their application in traditional Chinese medicine and Western medicine therapies， in order to provide new thoughts for the treatment of hepatic fibrosis.

     

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