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Volume 41 Issue 4
Apr.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(4): 742-747

Mechanism of action of sex hormones in regulating T cell-mediated autoimmune hepatitis： A study based on the phenomenon of female bias

DOI: 10.12449/JCH250421
  • 1.

    Second Department of Gastroenterology，The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China

  • 2.

    The First Clinical College of Heilongjiang University of Chinese Medicine，Harbin 150040，China

Research funding:

The Fifth Batch of National TCM Clinical Excellent Talents Training Project of the State Administration of Traditional Chinese Medicine （The Teaching Letter of Chinese Medicine ［2022］ No.1） ;

Heilongjiang Province Traditional Chinese Medicine Research Fund Project (ZHY2023-125)

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  • Corresponding author: LI Ming， harbinxin@163.com （ORCID： 0009-0000-7315-464X）
  • Received Date: 2024-07-24
  • Accepted Date: 2024-09-04
  • Published Date: 2025-04-25
    Abstract
  • Autoimmune hepatitis （AIH） is an autoimmune disease characterized by liver parenchymal destruction and chronic fibrosis， and it is often mediated by T cells. The pathogenesis of AIH involves multiple factors， including sex， region， environmental factors， and genetic susceptibility. A notable predisposition is observed in female individuals， and the incidence rate of AIH in female individuals is significantly higher than that in male individuals. This sex difference is associated with various factors， and sex hormones may be an important cause of the female predominance of AIH， although the specific mechanisms remain unclear. An in-depth understanding of the mechanism of action of sex hormones in the pathogenesis of AIH will help to better understand the pathogenesis of the disease and may provide important clues for developing future treatment methods and prevention strategies. This article reviews the mechanism of action of estrogen and androgen in regulating the pathogenesis of AIH by regulating T cells， in order to provide new ideas and directions for further exploring the potential role of sex hormones in the etiology of autoimmune diseases.

     

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