Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

Zhipeng WU; Yuqin ZHANG; Chun YAO; Minggang WANG; Na WANG; Mengru PENG; Ningfang MO; Yaqing ZHENG; Rongzhen ZHANG; Dewen MAO

doi:10.12449/JCH250226

Volume 41 Issue 2

Feb. 2025

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2025 > 41(2): 370-374

PDF( 923 KB)

Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

DOI: 10.12449/JCH250226

1.
First Ward of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China
2.
School of Pre-clinical Medicine，Guangxi Medical University，Nanning 530021，China
3.
Department of Acupuncture and Moxibustion，Guang’anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China

Research funding:

National Natural Science Foundation of China (82160881);

National Natural Science Foundation of China (82260899);

Guangxi Key Research and Development Plan Project (Guike AB22035076);

Guangxi University of Chinese Medicine ‘Qihuang Project’ High-Level Talent Team Training Project (202409);

Guangxi University of Chinese Medicine Inheritance Innovation Team Project (2022A001);

The First Affiliated Hospital of Guangxi University of Chinese Medicine Youth Top-Notch Talent Training Object Funding Project (yuandangzi［2022］46)

More Information

Corresponding author: ZHANG Rongzhen， zhangrongzhen2007@163.com （ORCID： 0000-0003-2243-665X）; MAO Dewen， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）
Received Date: 2024-05-29
Accepted Date: 2024-06-24
Published Date: 2025-02-25

Abstract

Abstract

Hepatic encephalopathy is a difficult and critical disease with rapid progression and limited treatment methods in the field of liver disease， and it is urgently needed to make breakthroughs in its pathogenesis. Selection of appropriate prevention and treatment strategies is of great importance in delaying disease progression and reducing the incidence and mortality rates. This article reviews the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine， proposes a new theory of “turbid toxin pathogenesis”， analyzes the scientific connotations of “turbid”， “toxin”， and the theory of “turbid toxin pathogenesis”， and constructs the “four-step” prevention and treatment strategies for hepatic encephalopathy， thereby establishing the new clinical prevention and treatment regimen for hepatic encephalopathy represented by “four prescriptions and two techniques” and clarifying the effect mechanism and biological basis of core prescriptions and techniques in the prevention and treatment of hepatic encephalopathy， in order to provide a reference for the prevention and treatment of hepatic encephalopathy.
- Hepatic Encephalopathy,
- Turbid Toxin Pathogenic,
- Therapeutics

FullText(HTML)

References(30)

References

[1]	ROSE CF, AMODIO P, BAJAJ JS, et al. Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy[J]. J Hepatol, 2020, 73( 6): 1526- 1547. DOI: 10.1016/j.jhep.2020.07.013.
[2]	TAPPER EB, PARIKH ND. Diagnosis and management of cirrhosis and its complications: A review[J]. JAMA, 2023, 329( 18): 1589- 1602. DOI: 10.1001/jama.2023.5997.
[3]	WANG XB, SHI K. Integrated traditional Chinese and western medicine diagnosis and treatment of hepatic encephalopathy: Advances and perspectives[J]. J Clin Hepatol, 2022, 38( 9): 1969- 1973. DOI: 10.3969/j.issn.1001-5256.2022.09.004. 王宪波, 时克. 肝性脑病的中西医结合诊疗进展与展望[J]. 临床肝胆病杂志, 2022, 38( 9): 1969- 1973. DOI: 10.3969/j.issn.1001-5256.2022.09.004.
[4]	WAN LF. Clinical experience of chief physician SHAO Ming treating hepatic encephalopathy[J]. J Chengdu Univ Tradit Chin Med, 2010, 33( 3): 38, 44. DOI: 10.13593/j.cnki.51-1501/r.2010.03.010. 万凌峰. 邵铭主任医师辨证论治肝性脑病经验[J]. 成都中医药大学学报, 2010, 33( 3): 38, 44. DOI: 10.13593/j.cnki.51-1501/r.2010.03.010.
[5]	JIANG HN, MAO DW, YE QL, et al. Research progress on TCM syndrome differentiation and treatment of hepatic encephalopathy[J]. Shaanxi J Tradit Chin Med, 2020, 41( 11): 1678- 1680. DOI: 10.3969/j.issn.1000-7369.2020.11.042. 蒋海南, 毛德文, 叶倩伶, 等. 中医辨证论治肝性脑病研究进展[J]. 陕西中医, 2020, 41( 11): 1678- 1680. DOI: 10.3969/j.issn.1000-7369.2020.11.042.
[6]	PANG YZ, LI WW. Zhuang Medicine internal pediatrics[M]. Beijing: China Press of Traditional Chinese Medicine, 2018. 庞宇舟, 李伟伟. 壮医内儿科学[M]. 北京: 中国中医药出版社, 2018.
[7]	BAI WJ, PAN PP, SHI QL, et al. Discussion on the pathogenic theory of“turbidity-toxin” in hepatic encephalopathy[J]. J Basic Chin Med, 2023, 29( 5): 727- 730. DOI: 10.19945/j.cnki.issn.1006-3250.2023.05.005. 柏文婕, 潘佩佩, 石清兰, 等. 基于“浊毒致病”学说探讨肝性脑病病因病机[J]. 中国中医基础医学杂志, 2023, 29( 5): 727- 730. DOI: 10.19945/j.cnki.issn.1006-3250.2023.05.005.
[8]	Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the management of hepatic encephalopathy in cirrhosis[J]. J Clin Hepatol, 2018, 34( 10): 2076- 2089. DOI: 10.3969/j.issn.1001-5256.2018.10.007. 中华医学会肝病学分会. 肝硬化肝性脑病诊疗指南[J]. 临床肝胆病杂志, 2018, 34( 10): 2076- 2089. DOI: 10.3969/j.issn.1001-5256.2018.10.007.
[9]	LIN Y, YAN GJ, FENG F, et al. Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy[J]. Open Life Sci, 2022, 17( 1): 139- 154. DOI: 10.1515/biol-2021-0140.
[10]	TANG YF, LIU XD, WANG WX, et al. Clinical characteristics and relatedinfluencing factors of minimalhepatic encephalopathy in patients with liver cirrhosis[J]. Infect Dis Inf, 2022, 35( 4): 316- 320. DOI: 10.3969/j.issn.1007-8134.2022.04.006. 唐艳芳, 刘旭东, 王文鑫, 等. 肝硬化合并轻微型肝性脑病的临床特点以及相关影响因素分析[J]. 传染病信息, 2022, 35( 4): 316- 320. DOI: 10.3969/j.issn.1007-8134.2022.04.006.
[11]	WANG TS, ZHANG RZ, WANG MG, et al. Theoretical connotations of liver failure“toxic pathogen-toxic turbidity” theory from the angle of“gut-liver axis”[J]. West J Tradit Chin Med, 2022, 35( 6): 67- 70. DOI: 10.12174/j.issn.2096-9600.2022.06.18. 王挺帅, 张荣臻, 王明刚, 等. 从“肠肝轴”角度诠释肝衰竭“毒邪-毒浊”学说的理论内涵[J]. 西部中医药, 2022, 35( 6): 67- 70. DOI: 10.12174/j.issn.2096-9600.2022.06.18.
[12]	SHI QL, HUANG ZH, BAI WJ, et al. Construction and practice of“four-step”prevention and treatment strategy for hepatic encephalopathy[J]. Chin J Integr Tradit West Med Liver Dis, 2023, 33( 2): 166- 168. DOI: 10.3969/j.issn.1005-0264.2023.002.019. 石清兰, 黄祖鸿, 柏文婕, 等. 肝性脑病“四步曲”防治策略的构建与实践[J]. 中西医结合肝病杂志, 2023, 33( 2): 166- 168. DOI: 10.3969/j.issn.1005-0264.2023.002.019.
[13]	WANG S, WANG N, MAO DW, et al. Clinical observation on the effect of Liuwei xingshen granules combined with mirabilite retention Enema in the treatment of type C hepatic encephalopathy and the regulation of acid-base imbalance[J]. Tradit Chin Med J, 2023, 22( 11): 28- 31. DOI: 10.14046/j.cnki.zyytb2002.2023.11.015. 王沙, 王娜, 毛德文, 等. 六味醒神颗粒加芒硝保留灌肠治疗C型肝性脑病及调节酸碱失衡作用的临床观察[J]. 中医药通报, 2023, 22( 11): 28- 31. DOI: 10.14046/j.cnki.zyytb2002.2023.11.015.
[14]	YAO C, XIE W, FU L. Jiedu Huayu Decoction science, learning and memory in the rats' behavior of the minor hepatic encephalopathy, toxins, ammonia, liver function and liver pathology affect plasma randomized controlled research[J]. J Pract Tradit Chin Intern Med, 2012, 26( 5): 7- 10. DOI: 10.3969/j.issn.1671-7813.2012.05.04. 姚春, 谢武, 付蕾. 解毒化瘀方对轻微型肝性脑病大鼠行为学、学习记忆能力、血浆内毒素、血氨、肝功能及肝脏病理影响随机平行对照研究[J]. 实用中医内科杂志, 2012, 26( 5): 7- 10. DOI: 10.3969/j.issn.1671-7813.2012.05.04.
[15]	LYU C, MAO DW, QIN Q, et al. Effect of Wenyang Huayu Tuihuang Decoction in the treatment of hepatitis B-related chronic and acute liver failure[J]. China Med Herald, 2019, 16( 30): 142- 146. 吕超, 毛德文, 覃倩, 等. 温阳化瘀退黄方治疗乙型肝炎相关慢加急性肝衰竭的效果[J]. 中国医药导报, 2019, 16( 30): 142- 146.
[16]	MA YZ, MAO DW, QIN YX, et al. Clinical effects of Liuwei xingshen granules in treating mild hepatic encephalopathy of liver cirrhosis and its influence on blood ammonia and endotoxin[J]. West J Tradit Chin Med, 2021, 34( 5): 7- 10. DOI: 10.12174/j.issn.2096-9600.2021.05.03. 马玉珍, 毛德文, 覃艳新, 等. 六味醒神颗粒治疗肝硬化轻微型肝性脑病的临床疗效及其对血氨和内毒素的影响[J]. 西部中医药, 2021, 34( 5): 7- 10. DOI: 10.12174/j.issn.2096-9600.2021.05.03.
[17]	WANG MG, WANG N, MAO DW, et al. The clinical research into minimal hepatic encephalopathy treated with Liuwei xingshen granule[J]. Henan Tradit Chin Med, 2016, 36( 12): 2112- 2114. DOI: 10.16367/j.issn.1003-5028.2016.12.0843. 王明刚, 王娜, 毛德文, 等. 六味醒神颗粒治疗轻微型肝性脑病临床研究[J]. 河南中医, 2016, 36( 12): 2112- 2114. DOI: 10.16367/j.issn.1003-5028.2016.12.0843.
[18]	WANG MG, MAO DW, WANG N, et al. Experimental study on regulating blood-brain barrier permeability of rats with mild hepatic encephalopathy by Liuwei Xingshen Granule[J]. Lishizhen Med Mater Med Res, 2016, 27( 7): 1619- 1621. DOI: 10.3969/j.issn.1008-0805.2016.07.027. 王明刚, 毛德文, 王娜, 等. 六味醒神颗粒调控轻微型肝性脑病大鼠血脑屏障通透性的实验研究[J]. 时珍国医国药, 2016, 27( 7): 1619- 1621. DOI: 10.3969/j.issn.1008-0805.2016.07.027.
[19]	WU N, MAO XK, WANG MG. Molecular mechanism of Liuwei xingshen granule(六味醒神颗粒) against hepatic encephalopathy based on network pharmacology and molecular docking[J]. Guid J Tradit Chin Med Pharm, 2020, 26( 5): 88- 92. DOI: 10.13862/j.cnki.cn43-1446/r.2020.05.023. 吴娜, 毛祥坤, 王明刚. 基于网络药理学及分子对接研究六味醒神颗粒治疗肝性脑病的分子作用机制[J]. 中医药导报, 2020, 26( 5): 88- 92. DOI: 10.13862/j.cnki.cn43-1446/r.2020.05.023.
[20]	HUANG GY, MAO DW, LONG FL, et al. Retention Enema with rhubarb decoction in treating hepatic encephalopathy: Results from a multi-center clinical trial[J]. Liaoning J Tradit Chin Med, 2011, 38( 7): 1364- 1366. DOI: 10.13192/j.ljtcm.2011.07.118.huanggy.032. 黄古叶, 毛德文, 龙富立, 等. 大黄煎剂保留灌肠治疗肝性脑病的多中心临床研究[J]. 辽宁中医杂志, 2011, 38( 7): 1364- 1366. DOI: 10.13192/j.ljtcm.2011.07.118.huanggy.032.
[21]	WANG N, WANG MG, MAO DW, et al. Clinical observation of rhubarb decoction in the treatment of type A hepatic encephalopathy[J]. Lishizhen Med Mater Med Res, 2015, 26( 5): 1169- 1171. DOI: 10.3969/j.issn.1008-0805.2015.05.053. 王娜, 王明刚, 毛德文, 等. 大黄煎剂治疗A型肝性脑病的临床疗效观察[J]. 时珍国医国药, 2015, 26( 5): 1169- 1171. DOI: 10.3969/j.issn.1008-0805.2015.05.053.
[22]	QIU H, HUANG GY, MAO DW, et al. Orthoplan to screen the optimum scheme of retention Enema in treatment of hepatic encephalopathy with rhubarb decoction[J]. J Tradit Chin Med, 2010, 51( 11): 990- 992. DOI: 10.13288/j.11-2166/r.2010.11.011. 邱华, 黄古叶, 毛德文, 等. 正交设计筛选大黄煎剂保留灌肠治疗肝性脑病最佳方案的研究[J]. 中医杂志, 2010, 51( 11): 990- 992. DOI: 10.13288/j.11-2166/r.2010.11.011.
[23]	TAN LC. Observation and nursing care of rhubarb decoction retention Enema in the treatment of hepatic encephalopathy[J]. Liaoning J Tradit Chin Med, 2007, 34( 8): 1116- 1117. DOI: 10.13192/j.ljtcm.2007.08.96.tanlch.051. 谭柳纯. 大黄煎剂保留灌肠治疗肝性脑病疗效观察及护理[J]. 辽宁中医杂志, 2007, 34( 8): 1116- 1117. DOI: 10.13192/j.ljtcm.2007.08.96.tanlch.051.
[24]	WU FL, LIAO NS, WEI JR, et al. Research progress of technical specification of the treatment of hepatic encephalopathy by Dahuang Decoction retention Enema[J]. West J Tradit Chin Med, 2023, 36( 6): 141- 144. DOI: 10.12174/j.issn.2096-9600.2023.06.34. 吴凤兰, 廖南盛, 卫家润, 等. 大黄煎剂保留灌肠治疗肝性脑病的技术规范研究进展[J]. 西部中医药, 2023, 36( 6): 141- 144. DOI: 10.12174/j.issn.2096-9600.2023.06.34.
[25]	ZHANG GF, CAI YY, LIN L, et al. Protective mechanism of rhubarb decoction against inflammatory damage of brain tissue in rats with mild hepatic encephalopathy: A study based on the PI3K/AKT/mTOR signaling pathway[J]. J Clin Hepatol, 2024, 40( 2): 312- 318. DOI: 10.12449/JCH240215. 张广发, 蔡颖莹, 林龙, 等. 基于PI3K/AKT/mTOR信号通路探讨大黄煎剂对轻微型肝性脑病大鼠脑组织炎症损伤的保护机制[J]. 临床肝胆病杂志, 2024, 40( 2): 312- 318. DOI: 10.12449/JCH240215.
[26]	DU YQ, WANG M, XU J, et al. Investigation of therapeutic effects of rhubarb decoction retention Enema on minimal hepatic encephalopathy in rats based on 16S rDNA gene sequencing and bile acid metabolomics[J]. J Pharm Biomed Anal, 2023, 230: 115392. DOI: 10.1016/j.jpba.2023.115392.
[27]	DU YQ, WANG M, HUANG GC, et al. Therapeutic effect of retention Enema with compound rhubarb decoction on a rat model of minimal hepatic encephalopathy based on bile acid metabolomics[J]. J Clin Hepatol, 2023, 39( 10): 2348- 2357. DOI: 10.3969/j.issn.1001-5256.2023.10.012. 杜沅沁, 王萌, 黄国初, 等. 基于胆汁酸代谢组学探讨复方大黄煎剂保留灌肠对轻微型肝性脑病大鼠模型的治疗作用[J]. 临床肝胆病杂志, 2023, 39( 10): 2348- 2357. DOI: 10.3969/j.issn.1001-5256.2023.10.012.
[28]	YAO C, HUANG GC, WANG M, et al. Chinese herbal medicine formula jieduhuayu granules improves cognitive and neurophysiological functions in patients with cirrhosis who have minimal hepatic encephalopathy: A randomized controlled trial[J]. Complement Ther Med, 2014, 22( 6): 977- 985. DOI: 10.1016/j.ctim.2014.10.005.
[29]	YAO C, WANG M, YAO F, et al. Clinical observation on intelligence test and neurophysiological changes of patients with mild hepatic encephalopathy treated with Jiedu Huayu recipe[J]. Lishizhen Med Mater Med Res, 2014, 25( 4): 890- 892. DOI: 10.3969/j.issn.1008-0805.2014.04.052. 姚春, 王萌, 姚凡, 等. 解毒化瘀方对轻微型肝性脑病患者智力测验及神经电生理学改变的临床观察[J]. 时珍国医国药, 2014, 25( 4): 890- 892. DOI: 10.3969/j.issn.1008-0805.2014.04.052.
[30]	MAO DW, QIU H, HUANG GY, et al. Experimental study on mechanism of detoxification and removing blood stasis formula II in preventing and treating hepatic encephalopathy in rats with AHG[J]. Tianjin J Tradit Chin Med, 2006, 23( 6): 486- 489. DOI: 10.3969/j.issn.1672-1519.2006.06.016. 毛德文, 邱华, 黄古叶, 等. 解毒化瘀Ⅱ方防治急性肝衰竭肝性脑病的实验机制研究[J]. 天津中医药, 2006, 23( 6): 486- 489. DOI: 10.3969/j.issn.1672-1519.2006.06.016.

Relative Articles

[1]	Wendi LIU, Peng WANG, Heping HU, Huabang ZHOU. ABCB4 gene mutation-associated liver cirrhosis with gallstones： A case report[J]. Journal of Clinical Hepatology, 2024, 40(3): 585-588. doi: 10.12449/JCH240324
[2]	Dan YANG, Cuiwei ZHANG, Mingming DENG. A compound heterozygous mutation in the ATP7B gene with acute fatty liver of pregnancy: A case report[J]. Journal of Clinical Hepatology, 2022, 38(1): 167-169. doi: 10.3969/j.issn.1001-5256.2022.01.027
[3]	Xianmei GAO, Xiaoxiao YU, Zhen YU, Linlin ZHANG, Jie YANG. Homozygous mutation in monozygotic twins in a family with hepatolenticular degeneration[J]. Journal of Clinical Hepatology, 2022, 38(9): 2120-2122. doi: 10.3969/j.issn.1001-5256.2022.09.032
[4]	Lei HUA, Quan SUN, Wenbin XU, Long ZHANG, Gongqiang WANG. ABCB4 gene mutation-associated liver cirrhosis misdiagnosed as Wilson's disease: A case report[J]. Journal of Clinical Hepatology, 2021, 37(6): 1419-1420. doi: 10.3969/j.issn.1001-5256.2021.06.039
[5]	Shuqin LI, Jing ZHOU, Yuan GAO, Xiaoyan MA, Liping WANG. Antiviral effect of entecavir in chronic hepatitis B patients with rtA181V/T mutation[J]. Journal of Clinical Hepatology, 2021, 37(5): 1053-1058. doi: 10.3969/j.issn.1001-5256.2021.05.016
[6]	Yong ZHANG, Zhengfa MAO. Association of tuberous sclerosis gene 1/2 mutations with the progression of hepatocellular carcinoma and prognosis[J]. Journal of Clinical Hepatology, 2021, 37(1): 84-88. doi: 10.3969/j.issn.1001-5256.2021.01.017
[7]	Xu Shuai, Zhang LiPing. Research advances in the role of exosomes in non-neoplastic liver diseases[J]. Journal of Clinical Hepatology, 2020, 36(4): 940-943. doi: 10.3969/j.issn.1001-5256.2020.04.052
[8]	Lin Jian, Fang XueQing, Song YouLiang. A case of recurrent liver dysfunction caused by NBAS gene mutation[J]. Journal of Clinical Hepatology, 2020, 36(9): 2069-2071. doi: 10.3969/j.issn.1001-5256.2020.09.034
[9]	Yang Fan, Wang YiRou, Yu XiaoDan, Ma Xiong, Wang XiuMin. Congenital hepatic fibrosis with retinitis pigmentosa caused by mutations of the TMEM67 gene and CNGB1 gene: A case report[J]. Journal of Clinical Hepatology, 2020, 36(7): 1593-1595. doi: 10.3969/j.issn.1001-5256.2020.07.029
[10]	Zheng YiShan. Early diagnosis of liver disease during pregnancy should be taken seriously[J]. Journal of Clinical Hepatology, 2019, 35(7): 1435-1438. doi: 10.3969/j.issn.1001-5256.2019.07.005
[11]	Liang Chen, Bai Li, Zheng SuJun. Research advances in mutation characteristics of the UGT1A1 gene in Gilbert syndrome and its influence on intrahepatic and extrahepatic systems[J]. Journal of Clinical Hepatology, 2019, 35(7): 1632-1635. doi: 10.3969/j.issn.1001-5256.2019.07.046
[12]	Li Ning, Zhang Xin, Li Rui, Jiao Lin. Hepatolenticular degeneration with MTHFR gene mutation: A case report[J]. Journal of Clinical Hepatology, 2019, 35(11): 2549-2550. doi: 10.3969/j.issn.1001-5256.2019.11.033
[13]	Zhou HuaBang, Hu HePing. Challenges in precise treatment for primary liver cancer based on gene mutation[J]. Journal of Clinical Hepatology, 2017, 33(7): 1209-1210. doi: 10.3969/j.issn.1001-5256.2017.07.001
[14]	Pang Ting, Xing HuiChun. Correlation between drug-resistance gene mutations and hepatocellular carcinoma in patients with hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2017, 33(1): 82-86. doi: 10.3969/j.issn.1001-5256.2017.01.017
[15]	Zhang XiaoTong, Guo LiPing. Value of ultrasonic elastography in diagnosis of liver diseases[J]. Journal of Clinical Hepatology, 2016, 32(11): 2210-2213. doi: 10.3969/j.issn.1001-5256.2016.11.048
[16]	Chen Juan, Yin HuaBin. Main applications of diffusion-weighted magnetic resonance imaging in liver diseases[J]. Journal of Clinical Hepatology, 2015, 31(1): 139-142. doi: 10.3969/j.issn.1001-5256.2015.01.032
[17]	Guo HongMei, Zheng BiXia, Li Mei. Neonatal intrahepatic cholestasis caused by citrin deficiency due to SLC25A13 gene mutations: a clinical analysis of 21cases in Nanjing, China[J]. Journal of Clinical Hepatology, 2014, 30(11): 1127-1131. doi: 10.3969/j.issn.1001-5256.2014.11.008
[18]	Peng XiaoFang, Liu HaiYing. Research advances in circulating miRNAs for diagnosis of hepatobiliary diseases[J]. Journal of Clinical Hepatology, 2014, 30(9): 965-968. doi: 10.3969/j.issn.1001-5256.2014.09.032

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (1077) PDF downloads(6)

Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

DOI: 10.12449/JCH250226

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

DOI: 10.12449/JCH250226

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content