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Volume 40 Issue 11
Nov.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(11): 2332-2337

Mechanism of cuproptosis and its role in liver diseases

DOI: 10.12449/JCH241131
  • 1.

    Department of Hepatobiliary Surgery，The First Affiliated Hospital of Gannan Medical University，Ganzhou，Jiangxi 341000，China

  • 2.

    Department of Hepatobiliary Surgery，Renmin Hospital of Wuhan University，Wuhan 430060，China

Research funding:

National Key Research and Development Program (2022YFC2407304)

More Information
  • Corresponding author: WANG Xiaohua， 15856404@qq.com （ORCID： 0009-0006-4722-0942）
  • Received Date: 2024-02-24
  • Accepted Date: 2024-05-20
  • Published Date: 2024-11-25
    Abstract
  • Cuproptosis is a new type of cell death that depends on intracellular copper accumulation to trigger the aggregation of mitochondrial lipoacylated protein and the degradation of iron-sulfur cluster protein， with a different mechanism of action from autophagy， ferroptosis， pyroptosis， and necroptosis. Cuproptosis is closely association with the development of liver cancer and resistance to antitumor drugs， as well as the progression of various liver diseases such as hereditary liver diseases， nonalcoholic fatty liver disease， viral hepatitis， and liver cirrhosis. This article summarizes the mechanism of cuproptosis and its role in liver diseases， in order to provide a reference for further research and treatment of liver diseases.

     

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